{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:16:14Z","timestamp":1781871374387,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571517, 81801542"],"award-info":[{"award-number":["81571517, 81801542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BMU20160571"],"award-info":[{"award-number":["BMU20160571"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to examine the associations of maternal obesity in early pregnancy with adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort analysis was performed among 18,481 Chinese nulliparous women, using data from a 2006 to 2009 trial of prenatal micronutrient supplementation. Obesity was defined as BMI\u2009\u2265\u200927.5\u00a0kg\/m<jats:sup>2<\/jats:sup>. Interested outcomes included fetal loss (spontaneous abortion plus stillbirth), infant death, total mortality, and preterm and birth weight outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with normal weight, obesity was associated with total mortality (adjusted relative risks [ARR] 1.34; 95% CI: 1.03\u20101.74) and fetal loss (ARR 1.51; 95% CI: 1.15\u20101.99) but not with infant death (ARR 0.53; 95% CI: 0.20\u20101.46). Further analyses showed that obesity was particularly associated with spontaneous abortion (ARR 1.51; 95% CI: 1.13\u20102.02) rather than stillbirth (ARR 1.52; 95% CI: 0.65\u20103.57). Moreover, obesity was associated with preterm birth (ARR 1.59; 95% CI: 1.25\u20102.02), macrosomia (ARR 3.71, 95% CI: 3.01\u20104.59), and large for gestational age (ARR 2.93; 95% CI: 2.49\u20103.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal obesity in early pregnancy is associated with various adverse pregnancy outcomes in Chinese nulliparous women, suggesting the importance of an appropriate weight before and during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22478","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T05:02:29Z","timestamp":1557378149000},"page":"1030-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Association of Maternal Obesity in Early Pregnancy with Adverse Pregnancy Outcomes: A Chinese Prospective Cohort Analysis"],"prefix":"10.1002","volume":"27","author":[{"given":"Yubo","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtian","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-6084","authenticated-orcid":false,"given":"Jianmeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62187-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.09.011"},{"key":"e_1_2_5_4_1","volume-title":"Levels and Trends in Child Mortality: Report 2015. 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