{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:07:43Z","timestamp":1792112863376,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK-096311"],"award-info":[{"award-number":["R01-DK-096311"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1-12-BS-58"],"award-info":[{"award-number":["1-12-BS-58"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7-13-MI-05"],"award-info":[{"award-number":["7-13-MI-05"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Methionine restriction (MR) decreases inflammation and improves markers of metabolic disease in rodents. MR also increases hepatic and circulating concentrations of fibroblast growth factor 21 (FGF21). Emerging evidence has suggested that FGF21 exerts anti\u2010inflammatory effects. The purpose of this study was to determine the role of FGF21 in mediating the MR\u2010induced reduction in inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wild\u2010type and <jats:italic>Fgf21<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice were fed a high\u2010fat (HF) control or HF\u2010MR diet for 8 weeks. In a separate experiment, mice were fed a HF diet (HFD) for 10 weeks. Vehicle or recombinant FGF21 (13.6 \u00b5g\/d) was administered via osmotic minipump for an additional 2 weeks. Inflammation and metabolic parameters were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Fgf21<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice were more susceptible to HFD\u2010induced inflammation, and MR reduced inflammation in white adipose tissue (WAT) and liver of <jats:italic>Fgf21<\/jats:italic><jats:sup>\u2010\/\u2010<\/jats:sup> mice. MR downregulated activity of signal transducer and activator of transcription 3 in WAT of both genotypes. FGF21 administration reduced hepatic lipids and blood glucose concentrations. However, there was little effect of FGF21 on inflammatory gene expression in liver or adipose tissue or circulating cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MR reduces inflammation independent of FGF21 action. Endogenous FGF21 is important to protect against the development of HFD\u2010induced inflammation in liver and WAT, yet administration of low\u2010dose FGF21 has little effect on markers of inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22534","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:14:27Z","timestamp":1560788067000},"page":"1305-1313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action"],"prefix":"10.1002","volume":"27","author":[{"given":"Shaligram","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Nutrition Georgia State University Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Nutrition Georgia State University Atlanta Georgia 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