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Patients completed the Dutch Eating Behavior Questionnaire and resting\u2010state functional magnetic resonance imaging scanning to measure\u00a0FC. Data were analyzed using a seed\u2010to\u2010voxel approach in the CONN Toolbox to investigate pre\u2010\/postsurgery changes (<jats:italic>n<\/jats:italic>\u2009=\u200912) and to conduct predictive analysis (<jats:italic>n<\/jats:italic>\u2009=\u200914).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seed\u2010to\u2010voxel analysis revealed changes in magnitude (decreases) and directionality (positively correlated to anticorrelated) of FC pre to post\u00a0surgery within and between default mode network, salience network, and frontoparietal network nodes [Family\u2010Wise Error (FWE) corrected at <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05]. Baseline FC of the nucleus accumbens (with insula) and hypothalamus (with precentral gyrus) predicted 12\u2010month post\u2010SG % total weight loss (FWE\u2010<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Baseline FC of the hippocampus, frontoparietal network, and default mode network nodes predicted improvement in cognitive control of eating behavior 12 months\u00a0after SG (FWE\u2010<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate changes in FC magnitude and directionality post versus pre\u00a0surgery within and between resting\u2010state networks and frontal, paralimbic, and visual areas in SG patients. Baseline FC predicted weight loss and changes in cognitive control of food intake behavior at 12 months. These could serve as predictive biomarkers for bariatric surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22607","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T15:52:25Z","timestamp":1572969145000},"page":"1846-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Resting\u2010State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy"],"prefix":"10.1002","volume":"27","author":[{"given":"Hil\u00e2l","family":"Cerit","sequence":"first","affiliation":[{"name":"Division of Women\u2019s Health, Department of Medicine Brigham and Women\u2019s Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Davidson","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Psychiatry Brigham and Women\u2019s Hospital Boston Massachusetts USA"},{"name":"Center for Metabolic and Bariatric Surgery, Department of Surgery Brigham and Women\u2019s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taryn","family":"Hye","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Department of Medicine Brigham and Women\u2019s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Moondra","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Department of Medicine Brigham and Women\u2019s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florina","family":"Haimovici","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Psychiatry Brigham and Women\u2019s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Sogg","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"MGH Weight Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Shikora","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Center for Metabolic and Bariatric Surgery, Department of Surgery Brigham and Women\u2019s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Department of Medicine Brigham and Women\u2019s Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Division of Psychiatric Neuroscience, Athinoula A. 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