{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:12:32Z","timestamp":1773947552277,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1R01DK115503"],"award-info":[{"award-number":["1R01DK115503"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Amphetamine was formerly used as a treatment to combat obesity, but amphetamine\u2019s use as an appetite suppressant was discontinued because of its significant abuse potential. Most of the rewarding and reinforcing effects of amphetamine differ by sex, with females showing higher levels of drug intake and amphetamine\u2010induced motivation, relapse, and locomotion, but it is unknown\u00a0whether amphetamine\u2019s effects on feeding also differ by sex. Furthermore, previous research on the anorectic effects of amphetamine has been focused primarily on its effects on baseline homeostatic feeding, but it is unknown whether amphetamine also affects hedonic, reward\u2010related feeding, which is an important factor driving the rise in obesity levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study\u00a0tested whether amphetamine alters food intake in a sex\u2010dependent manner in two reward\u2010related feeding paradigms: a sucrose two\u2010bottle choice test and a high\u2010fat\/high\u2010sugar binge intake model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amphetamine altered food intake equally in males and females in both paradigms, with higher doses significantly inhibiting feeding and low doses of amphetamine increasing feeding at later time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Amphetamine\u2019s effects on feeding and drug reward may be mediated by distinct mechanisms, which could allow for the development of new approaches to combat obesity with limited abuse and addiction\u2010related side effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22636","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T04:59:45Z","timestamp":1569646785000},"page":"1874-1882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Amphetamine Dose\u2010Dependently Decreases and Increases Binge Intake of Fat and Sucrose Independent of Sex"],"prefix":"10.1002","volume":"27","author":[{"given":"Katherine Stuhrman","family":"West","sequence":"first","affiliation":[{"name":"Department of Biology Georgia State University Atlanta Georgia USA"},{"name":"Neuroscience Institute Georgia State University Atlanta Georgia 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