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Then associations of nine metabolite patterns derived from principal components analysis with phenotype after accounting for age, sex, race, and pubertal status were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five metabolite patterns differed with respect to phenotype: factor 1 consisted of long\u2010chain fatty acids and was lower among non\u2010OWOB and high MetRisk (\u22120.90 [95% CI: \u22121.39 to \u22120.42]) versus non\u2010OWOB and low MetRisk (referent); factors 5 (branched\u2010chain amino acids), 8 (diacylglycerols), and 9 (steroid hormones) were highest among OWOB and high MetRisk; and factor 7 (long\u2010chain acylcarnitines) was higher among non\u2010OWOB and high MetRisk (0.47 [95% CI: 0.04 to 0.91]) and lower among OWOB and low MetRisk (\u22120.36 [95% CI: \u22120.68 to \u22120.04]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010chain fatty acids, branched\u2010chain amino acids, acylcarnitines, diacylglycerols, and steroid hormones differed by weight status and metabolic phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22694","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T10:45:28Z","timestamp":1577357128000},"page":"379-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Metabolomic Profiles of Overweight\/Obesity Phenotypes During Adolescence: A Cross\u2010Sectional Study in Project Viva"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-6850","authenticated-orcid":false,"given":"Wei","family":"Perng","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health University of Colorado Denver Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse (CoRAL) Department of Population Medicine Harvard Medical School\/Harvard Pilgrim Health Care Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sordillo","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse (CoRAL) Department of Population Medicine Harvard Medical School\/Harvard Pilgrim Health Care Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse (CoRAL) Department of Population Medicine Harvard Medical School\/Harvard Pilgrim Health Care Institute Boston Massachusetts USA"},{"name":"Diabetes Unit Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse (CoRAL) Department of Population Medicine Harvard Medical School\/Harvard Pilgrim Health Care Institute Boston Massachusetts USA"},{"name":"Diabetes Unit Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Department of Nutrition T. 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