{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:03:30Z","timestamp":1793833410886,"version":"4.6.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to test the feasibility of a combined intervention involving transcranial direct current stimulation (tDCS) on the dorsolateral prefrontal cortex (dlPFC) and cognitive training (CT). Short\u2010term effects on food consumption, cognition, endocannabinoid (eCB) levels, and electroencephalogram (EEG)\u00a0markers of future weight loss were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen healthy volunteers with morbid obesity were randomized in a double\u2010blind, placebo\u2010controlled, parallel trial. Participants received sham or active tDCS plus CT for four consecutive days. Cognitive performance, daily food intake, and eCB blood samples were collected before and after the intervention; EEG data were gathered before and after daily training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The active tDCS\u2009+\u2009CT group reversed left\u2010dominant frontal asymmetry and increased frontal coherence (FC) in the \u03b3\u2010band (30\u201045 Hz) after the intervention. The strength of the latter predicted BMI reduction. Additionally, a large intervention effect on food intake was shown in the active tDCS\u2009+\u2009CT group at follow\u2010up (\u2212339.6\u2009\u00b1\u2009639 kcal on average), and there was a decrease of plasma eCB concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>dlPFC modulation through tDCS\u2009+\u2009CT is an effective tool to restore right dominance of the dlPFC and enhance FC in patients with morbid obesity. Moreover, the effect of the strength of FC on BMI suggests that the interhemispheric FC at the dlPFC is functionally relevant for the efficient regulation of food choice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22745","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T05:33:42Z","timestamp":1583559222000},"page":"696-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prefrontal Cortex Neuromodulation Enhances Frontal Asymmetry and Reduces Caloric Intake in Patients with Morbid Obesity"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8478-1451","authenticated-orcid":false,"given":"Laura","family":"Forcano","sequence":"first","affiliation":[{"name":"Neurosciences Research Program. 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Integrative Pharmacology and Systems Neuroscience Group IMIM\u2010Hospital del Mar Medical Research Institute Barcelona Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Langohr","sequence":"additional","affiliation":[{"name":"Neurosciences Research Program. Integrative Pharmacology and Systems Neuroscience Group IMIM\u2010Hospital del Mar Medical Research Institute Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Casta\u00f1er","sequence":"additional","affiliation":[{"name":"Neurosciences Research Program. Integrative Pharmacology and Systems Neuroscience Group IMIM\u2010Hospital del Mar Medical Research Institute Barcelona Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Alejandra","family":"P\u00e9rez\u2010Vega","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Risk and Nutrition IMIM\u2010Hospital del Mar Medical Research Institute Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Serra","sequence":"additional","affiliation":[{"name":"Morbid Obesity Care Unit IMIM\u2010Hospital del Mar Medical Research Institute Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Ruffini","sequence":"additional","affiliation":[{"name":"Starlab Barcelona SL Barcelona Spain"},{"name":"Neuroelectrics Corporation Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alonso\u2010Alonso","sequence":"additional","affiliation":[{"name":"Laboratory of Bariatric and Nutritional Neuroscience Center for the Study of Nutrition Medicine Beth Israel Deaconess Medical Center Harvard Medical School, Harvard University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aureli","family":"Soria\u2010Frisch","sequence":"additional","affiliation":[{"name":"Starlab Barcelona SL Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Neurosciences Research Program. 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