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This study hypothesized that impaired satiation responses contribute to elevated intake in an INT\u2010HFD access model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, this study characterized the intake and meal patterns of female rats that were subjected to an INT HFD in which a 45% HFD was presented for 20 hours every fourth day. To examine nutrient\u2010induced satiation, rats received intragastric infusions of saline or Ensure Plus prior to darkness\u2010onset food access. A similar design was used to examine sensitivity to the satiating effect of amylin. This study then examined whether an INT HFD influences amylin\u2010induced c\u2010Fos in feeding\u2010relevant brain areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Upon INT HFD access, rats consumed meals of larger size. The anorexic response to intragastric Ensure infusion and exogenous amylin treatment was blunted in INT rats on both chow\u2010only and INT\u2010HFD days of the diet regimen, compared with chow\u2010maintained and continuous\u2010HFD rats. An INT HFD did not influence amylin\u2010induced c\u2010Fos in the area postrema, nucleus of the solitary tract, and lateral parabrachial nucleus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Impaired satiation responses, mediated in part by reduced sensitivity to amylin, may explain the elevated intake observed upon INT HFD access and may play a role in disorders of INT overconsumption, including binge eating.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22779","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T15:40:02Z","timestamp":1585755602000},"page":"942-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intermittent High\u2010Fat Diet Intake Reduces Sensitivity to Intragastric Nutrient Infusion and Exogenous Amylin in Female 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