{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T09:15:27Z","timestamp":1782378927311,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>People with diabetes show great variability in weight \n\ngain and duration of obesity at the time of diagnosis. BMI trajectories and other cardiometabolic risk factors prior to type 2 diabetes \n\nwere investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 6,223 participants \n\nfrom the Rotterdam Study cohort were included. BMI patterns before diagnosis of diabetes were identified through latent class \n\ntrajectories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow\u2010up of \n\n13.7 years, 565 participants developed type 2 diabetes. Three distinct trajectories of BMI\u00a0were identified, including the \n\n\u201cprogressive overweight\u201d group (<jats:italic>n<\/jats:italic>\u2009=\u2009481, 85.1%), \u201cprogressive weight loss\u201d group \n\n(<jats:italic>n<\/jats:italic>\u2009=\u200959, 10.4%), and \u201cpersistently high BMI\u201d group (<jats:italic>n<\/jats:italic>\u2009=\u200925, 4.4%). The \n\nmajority, the progressive overweight group, was characterized by a steady increase of BMI in the overweight range 10 years before \n\ndiabetes diagnosis. The progressive weight loss\u00a0group had fluctuations of glucose and marked beta cell function loss. The \n\npersistently high BMI group was characterized by a slight increase in insulin levels and sharp increase of insulin resistance \n\naccompanied by a rapid decrease of beta cell function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\n\n<\/jats:title><jats:p>Heterogeneity of BMI changes prior to type 2 diabetes was found in a middle\u2010aged and elderly white population. \n\nPrevention strategies should be tailored rather than focusing only on high\u2010risk individuals.\n\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22802","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T14:44:37Z","timestamp":1588862677000},"page":"1149-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Trajectories of BMI Before Diagnosis of Type 2 Diabetes: The Rotterdam Study"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-5491","authenticated-orcid":false,"given":"Jana","family":"Nano","sequence":"first","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Institute of Epidemiology Helmholtz Zentrum Munich German Research Center for Environmental Health Neuherberg Germany"},{"name":"German Diabetes Center (DZD) Munich  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klodian","family":"Dhana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Geriatrics and Palliative Medicine Rush Medical College Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eralda","family":"Asllanaj","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sijbrands","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Biostatistics and Epidemiology MRC\u2010PHE Centre for Environment and Health School of Public Health Imperial College London London UK"},{"name":"UK Dementia Research Institute (UK DRI), Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taulant","family":"Muka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Institute of Social and Preventive Medicine (ISPM) University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Institute of Social and Preventive Medicine (ISPM) University of Bern Bern 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