{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:32:16Z","timestamp":1791999136170,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1122190"],"award-info":[{"award-number":["1122190"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1133622"],"award-info":[{"award-number":["1133622"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011890","name":"Wesley Medical Research","doi-asserted-by":"publisher","award":["2015\u201017"],"award-info":[{"award-number":["2015\u201017"]}],"id":[{"id":"10.13039\/100011890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the effect of exercise intensity on visceral adipose tissue (VAT) and liver fat reduction in patients with coronary artery disease (CAD) over 3 months and the maintenance of improvements over 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two participants with CAD were randomized to three sessions\/week of either 4\u2009\u00d7\u20094\u2010minute high\u2010intensity interval training (HIIT) or 40 minutes of usual care moderate\u2010intensity continuous training (MICT) for a 4\u2010week supervised cardiac rehabilitation program, followed by three home\u2010based sessions\/week for 11 months. Liver fat (as intrahepatic lipid) and VAT were measured via magnetic resonance techniques. Data are mean change (95% CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HIIT and MICT significantly reduced VAT over 3 months (\u2212350 [\u2212548 to \u2212153] cm<jats:sup>3<\/jats:sup> vs. \u2212456 [\u2212634 to \u2212278] cm<jats:sup>3<\/jats:sup>; time\u2009\u00d7\u2009group effect: <jats:italic>P<\/jats:italic>\u2009=\u20090.421), with further improvement over 12 months (\u2212545 [\u2212818 to \u2212271] cm<jats:sup>3<\/jats:sup> vs. \u2212521 [\u2212784 to \u2212258] cm<jats:sup>3<\/jats:sup>; time\u2009\u00d7\u2009group effect: <jats:italic>P<\/jats:italic>\u2009=\u20090.577) and no differences between groups. Both groups improved liver fat over 3 months, with HIIT tending to show greater reduction than MICT (\u22122.8% [\u22124.0% to \u22121.6%] vs. \u22121.4% [\u22122.4% to \u22120.4%]; time\u2009\u00d7\u2009group effect: <jats:italic>P<\/jats:italic>\u2009=\u20090.077). After 12 months, improvements were maintained to a similar degree. Higher exercise intensity predicted liver fat reduction (\u03b2\u2009=\u2009\u22120.3 [\u22120.7 to 0.0]; <jats:italic>P<\/jats:italic>\u2009=\u20090.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIIT and MICT reduced VAT over 3 and 12 months. For liver fat, HIIT tended to provide a slightly greater reduction compared with MICT. These findings support HIIT as a beneficial adjunct or alternative to MICT for reducing visceral and liver fat in patients with CAD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22833","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T11:54:50Z","timestamp":1590926090000},"page":"1245-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of High\u2010Intensity Interval Training on Visceral and Liver Fat in Cardiac Rehabilitation: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-2714","authenticated-orcid":false,"given":"Jenna L.","family":"Taylor","sequence":"first","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"},{"name":"Cardiac Rehabilitation Department The Wesley Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6076-4617","authenticated-orcid":false,"given":"David J.","family":"Holland","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"},{"name":"Department of Cardiology Sunshine Coast University Hospital Birtinya Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-2715","authenticated-orcid":false,"given":"Gregore I.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-2780","authenticated-orcid":false,"given":"Tom G.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-5625","authenticated-orcid":false,"given":"Michael D.","family":"Leveritt","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6808-0180","authenticated-orcid":false,"given":"Sjaan R.","family":"Gomersall","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"},{"name":"School of Health and Rehabilitation Sciences The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-697X","authenticated-orcid":false,"given":"Alex V.","family":"Rowlands","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester General Hospital Leicester UK"},{"name":"NIHR Leicester Biomedical Research Centre Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6990-3596","authenticated-orcid":false,"given":"Jeff S.","family":"Coombes","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-2721","authenticated-orcid":false,"given":"Shelley E.","family":"Keating","sequence":"additional","affiliation":[{"name":"Centre for Research on Exercise Physical Activity, and Health School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Queensland 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