{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:42:54Z","timestamp":1787938974298,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["PX2018001"],"award-info":[{"award-number":["PX2018001"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["QML20180103"],"award-info":[{"award-number":["QML20180103"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61527807"],"award-info":[{"award-number":["61527807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61801311"],"award-info":[{"award-number":["61801311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701644"],"award-info":[{"award-number":["81701644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7162048"],"award-info":[{"award-number":["7162048"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172064"],"award-info":[{"award-number":["7172064"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7182044"],"award-info":[{"award-number":["7182044"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate regional neural activity and regulation of patterns in\u00a0the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI)\u00a0data were acquired using 3.0\u2010T MRI. Amplitude of low\u2010frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Processing Assistant for resting\u2010state fMRI and Resting\u2010State fMRI Data Analysis Toolkit (REST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The group with obesity showed increased amplitude of low\u2010frequency values in left fusiform gyrus\/amygdala, inferior temporal gyrus (ITG), hippocampus\/parahippocampal gyrus, and bilateral caudate but decreased values in right superior temporal gyrus. The group with obesity showed increased FC between left caudate and right superior temporal gyrus, left fusiform gyrus\/amygdala and left ITG, right caudate and left fusiform gyrus\/amygdala, and right caudate and left hippocampus\/parahippocampal gyrus. Dutch Eating Behavior Questionnaire\u2010Emotional scores were positively correlated with FC between left hippocampus\/parahippocampal gyrus and right caudate but negatively correlated with FC between left fusiform gyrus\/amygdala and left ITG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study indicated the reorganized neural network presented as a bilateral cross\u2010regulation pattern across hemispheres between reward and various appetite\u2010related functional processing, thus affecting emotional and external eating behavior. These results could provide further evidence for neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential in obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22839","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T14:10:37Z","timestamp":1591625437000},"page":"1283-1291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Abnormal Regional Neural Activity and Reorganized Neural Network in Obesity: Evidence from Resting\u2010State fMRI"],"prefix":"10.1002","volume":"28","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010wei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Language Science and Art Jiang Su Normal University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010xia","family":"Yu","sequence":"additional","affiliation":[{"name":"Medical Imaging Center Beijing Tongren Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Beijing Friendship Hospital Capital Medical University &amp; National Clinical Research Center for Digestive Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Beijing Friendship Hospital Capital Medical University &amp; National Clinical Research Center for Digestive Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u2010yu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010shuai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010han","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-4777","authenticated-orcid":false,"given":"Han","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-6821","authenticated-orcid":false,"given":"Zhong\u2010tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Beijing Friendship Hospital Capital Medical University &amp; National Clinical Research Center for Digestive Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-6469","authenticated-orcid":false,"given":"Zhen\u2010chang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Obesity and overweight.http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/. Updated April 1 2020. Accessed December 8 2019."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2011.10.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.213"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.02.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08272-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22607"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000340"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2011.00927.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.07.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0278-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.06.004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2013.07.013"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1000-x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705006434"},{"key":"e_1_2_10_18_1","first-page":"295\u2010315","article-title":"Dutch Eating Behavior Questionnaire for assessment of restrained, emotional and external eating behaviour","volume":"5","author":"Strien T","year":"1986","journal-title":"Int J Eat Disord"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2016.1173712"},{"key":"e_1_2_10_20_1","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \u201cpipeline\u201d data analysis of resting\u2010state fMRI","volume":"4","author":"Chao\u2010Gan Y","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12221"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2014.00007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26576"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.016"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.066"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031089"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.125"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.055"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2012.735642"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.064"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0350-06.2006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.006304"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.011"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2008.02132.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20859"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20518"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-016-0589-7"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.031"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.026"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14188"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23222"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.02.007"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.56"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.22839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.22839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.22839","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.22839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:16:52Z","timestamp":1693811812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.22839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/oby.22839"],"URL":"https:\/\/doi.org\/10.1002\/oby.22839","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]},"assertion":[{"value":"2020-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}