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Obesity may lead to disruptions in hippocampal structure. In animals, obesity\u2010related factors (e.g., high\u2010fat\/sugar foods) are associated with hippocampal insult (e.g., alterations in the blood brain barrier). In humans, individuals with obesity, relative to healthy weight, have smaller hippocampal volumes. Few studies have examined the association between body weight and the hippocampus during adolescence, a critical brain development period. This study examined hippocampal volume and tissue signal intensity in adolescents across the weight spectrum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Structural magnetic resonance imaging and anthropomorphic data were available for 102 12\u2010 to 18\u2010year\u2010old adolescents (53% female; 15.07 [SD\u00a01.84] years; standardized BMI [BMI<jats:italic>z<\/jats:italic>] scores using the Centers for Disease Control and Prevention growth charts: 0.54 [SD\u00a01.17]) from the Pediatric Imaging, Neurocognition, and Genetics database. Linear regression models controlling for age, sex, genetic ancestry, scanner, and household income examined the relationship between BMI<jats:italic>z<\/jats:italic>, hippocampal volume, and T2\u2010weighted hippocampal signal intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMI<jats:italic>z<\/jats:italic> was negatively associated with T2\u2010weighted hippocampal signal intensity in the left (t\u2009=\u2009\u22123.05; <jats:italic>P<\/jats:italic>\u2009=\u20090.003; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.21) and right (t\u2009=\u2009\u22122.50; <jats:italic>P<\/jats:italic>\u2009=\u20090.01; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.36) hippocampi. BMI<jats:italic>z<\/jats:italic> was not significantly associated with hippocampal volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BMI<jats:italic>z<\/jats:italic> is associated with hippocampal tissue characteristics during adolescence, which could impact later brain development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22841","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T14:52:34Z","timestamp":1591368754000},"page":"1325-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Associations Between Body Weight, Hippocampal Volume, and Tissue Signal Intensity in 12\u2010 to 18\u2010Year\u2010Olds"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-3162","authenticated-orcid":false,"given":"Zoe","family":"Mestre","sequence":"first","affiliation":[{"name":"San Diego State University\u2013University of California San Diego Joint Doctoral Program in Clinical Psychology UCSD Center for Healthy Eating and Activity Research (CHEAR) La Jolla California USA"},{"name":"Department of Psychiatry University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Bischoff-Grethe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina E.","family":"Wierenga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego La Jolla California USA"},{"name":"Veterans Affairs San Diego Healthcare System Research Service San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Jernigan","sequence":"additional","affiliation":[{"name":"Department of Cognitive Science University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-2177","authenticated-orcid":false,"given":"Dawn M.","family":"Eichen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of Medecine Baltimore Maryland USA"},{"name":"Departrment of Neurology University of Maryland School of Medecine Baltimore Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear 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