{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:42:59Z","timestamp":1773394979859,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assessed the changes in red blood cell total phospholipid (RBC\u2010TPL) and subcutaneous adipose tissue (SAT) fatty acid (FA) composition in response to 12 weeks of exercise training in South African women with obesity and the associations with changes in cardiometabolic risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Previously sedentary women were randomized into control (<jats:italic>n<\/jats:italic>\u2009=\u200915) or exercise (<jats:italic>n<\/jats:italic>\u2009=\u200920) groups. RBC\u2010TPL and SAT FA profiles, SAT gene expression, systemic inflammatory markers, liver fat, and insulin sensitivity (S<jats:sub>I<\/jats:sub>) were measured before and after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with control, exercise training induced decreases in RBC\u2010TPL dihomo\u2010\u03b3\u2010linolenic acid content and stearoyl\u2010CoA desaturase\u20101 and increased delta\u20105 desaturase\u2013estimated activity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the combined group, these changes correlated with changes in circulating leptin and TNF\u03b1 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), as well as lower liver fat (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Exercise training decreased saturated FA (lauric and myristic acids) and increased polyunsaturated FA (eicosadienoic and adrenic acids) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in abdominal SAT, whereas \u03b3\u2010linolenic acid decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) in gluteal SAT. These changes in RBC\u2010TPL and SAT FA compositions were not associated with changes in SAT gene expression and S<jats:sub>I<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Exercise training alters RBC\u2010TPL desaturase activities, which correlate with lower liver fat and systemic inflammation but not with the improvement of S<jats:sub>I<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22862","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T11:45:52Z","timestamp":1594035952000},"page":"1456-1466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exercise Training Alters Red Blood Cell Fatty Acid Desaturase Indices and Adipose Tissue Fatty Acid Profile in African Women with Obesity"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9301-4556","authenticated-orcid":false,"given":"Pamela 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