{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:26:32Z","timestamp":1784575592689,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA21765"],"award-info":[{"award-number":["P30CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["Collaborative Influenza Vaccine Innovation Centers contract 75N93019C00052"],"award-info":[{"award-number":["Collaborative Influenza Vaccine Innovation Centers contract 75N93019C00052"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD006982"],"award-info":[{"award-number":["HD006982"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Individuals with obesity suffer from an increased susceptibility to severe respiratory viral infections and respond poorly to vaccinations, making it imperative to identify interventions. Recent evidence suggesting that obesity leads to tissue\u2010specific vitamin A deficiency led to an investigation of whether high\u2010dose oral vitamin A, a treatment used for remediating vitamin A deficiency in developing countries, could correct obesity\u2010associated tissue deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult C57BL\/6 diet\u2010induced obese mice were supplemented with vitamin A for 4\u00a0weeks. A subset of mice were then vaccinated with inactivated influenza virus and challenged. Following supplementation, tissue vitamin A levels, lung immune cell composition, blood inflammatory cytokines, antibody responses, and viral clearance were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Supplementation significantly improved vitamin A levels in lung and adipose tissues in diet\u2010induced obese mice. Additionally, supplementation decreased inflammatory cytokines in the blood and altered the lung immune environment. Importantly, vaccinated, vitamin A\u2013treated diet\u2010induced obese mice exhibited improved antibody responses and significantly reduced viral loads post challenge compared with PBS\u2010treated mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results demonstrate a low\u2010cost intervention that may correct vitamin A tissue deficits and help control respiratory viral infections in individuals with obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.22929","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T01:15:25Z","timestamp":1597108525000},"page":"1631-1636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin A Corrects Tissue Deficits in Diet\u2010Induced Obese Mice and Reduces Influenza Infection After Vaccination and Challenge"],"prefix":"10.1002","volume":"28","author":[{"given":"Rhiannon R.","family":"Penkert","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases St. Jude Children\u2019s Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Jude Children\u2019s Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Jude Children\u2019s Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi","family":"Livingston","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Jude Children\u2019s Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri 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Microbiology, Immunology and Biochemistry University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Hurwitz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Jude Children\u2019s Research Hospital Memphis Tennessee USA"},{"name":"Department of Microbiology, Immunology and Biochemistry University of Tennessee Health Science Center Memphis Tennessee 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