{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:18:23Z","timestamp":1767838703517,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Researchers have speculated that vaccines to prevent coronavirus disease 2019 (COVID\u201019) may be less effective for individuals with obesity, a major risk factor for mortality and morbidity from COVID\u201019. Initial results from the Pfizer\u2010BioNTech and Moderna COVID\u201019 vaccine trials, though limited by inadequate power to compare subgroups and incomplete stratification of high\u2010risk groups, appear to have similar efficacy among individuals with and without obesity. Careful follow\u2010up in placebo\u2010controlled studies is required to generate data on long\u2010term vaccine immunogenicity, particularly in high\u2010risk groups. Subsequent analyses should stratify safety and efficacy results by each class of obesity. Speculation about variable effectiveness of COVID\u201019 vaccines in obesity likely increases vaccine hesitancy among individuals with obesity, who face not only a higher risk of severe outcomes from COVID\u201019 but also weight stigma, which reduces health care engagement at baseline. Clinical and public health messaging must be data driven, transparent, and sensitive to these biological and sociological vulnerabilities.<\/jats:p>","DOI":"10.1002\/oby.23131","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T21:33:44Z","timestamp":1611869624000},"page":"634-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["COVID\u201019 Vaccination and Obesity: Optimism and Challenges"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-961X","authenticated-orcid":false,"given":"Matthew J.","family":"Townsend","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-5854","authenticated-orcid":false,"given":"Theodore K.","family":"Kyle","sequence":"additional","affiliation":[{"name":"ConscienHealth Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-533X","authenticated-orcid":false,"given":"Fatima Cody","family":"Stanford","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Medicine\u2010Division of Endocrinology\u2010Neuroendocrine Department of Pediatrics\u2010Division of Endocrinology Nutrition Obesity Research Center at Harvard (NORCH) Massachusetts General Hospital MGH Weight Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13128"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154316"},{"key":"e_1_2_4_4_1","unstructured":"United States Centers for Disease Control and Prevention.COVID\u201019: people at increased risk: people with certain medical conditions.https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/need\u2010extra\u2010precautions\/people\u2010with\u2010medical\u2010conditions.html. Updated February 22 2021. Accessed December 31 2020."},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_4_7_1","unstructured":"United States Food and Drug Administration.Meeting briefing document: Moderna COVID\u201019 vaccine.Vaccines and Related Biological Products Advisory Committee. December 17 2020.https:\/\/www.fda.gov\/advisory\u2010committees\/advisory\u2010committee\u2010calendar\/vaccines\u2010and\u2010related\u2010biological\u2010products\u2010advisory\u2010committee\u2010december\u201017\u20102020\u2010meeting\u2010announcement#event\u2010materials. Updated December 17 2020. Accessed December 26 2020."},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.101"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.25594"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170550"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2009.159491"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:19:00Z","timestamp":1693415940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/oby.23131"],"URL":"https:\/\/doi.org\/10.1002\/oby.23131","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"2021-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}