{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:15:32Z","timestamp":1792613732379,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study objective was to examine the association between phentermine\/topiramate therapy and weight loss and adverse events in adults with overweight or obesity by meta\u2010analysis and systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical Subject Headings and free\u2010text terms were selected to search for eligible trials in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase up to April 18, 2020. The quality of randomized controlled trials was evaluated by the Cochrane risk\u2010of\u2010bias tool. Meta\u2010analysis was performed using random\u2010effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phentermine\/topiramate therapy resulted in an average weight loss of 7.73 kg (95% CI: 6.60\u20108.85) in general compared with placebo. The weight loss was related to the dose of phentermine\/topiramate. Compared with placebo, the average weight loss was 3.55 kg (95% CI: 2.22\u20104.88) for 3.75\/23 mg, 7.27 kg (95% CI: 6.40\u20108.13) for 7.5\/46 mg, and 8.25 kg (95% CI: 6.92\u20109.79) for 15\/92 mg. For phentermine\/topiramate participants in different weight\u2010loss subgroups, the weight loss of participants with \u22655%, \u226510%, and \u226515% baseline weight loss was 3.18 (95% CI: 2.75\u20103.67), 5.32 (95% CI: 4.53\u20106.25), and 5.65 (95% CI: 3.55\u20109.01), respectively. Compared with placebo, the adverse events associated with the treatment mainly included dysgeusia (odds ratio [OR] = 8.86, 95% CI: 5.65\u201013.89), paresthesia (OR = 8.51, 95% CI: 6.20\u201011.67), dry mouth (OR = 6.71, 95% CI: 5.03\u20108.94), disturbance in attention (OR = 4.48, 95% CI: 2.39\u20108.41), irritability (OR = 4.10, 95% CI: 2.29\u20107.33), hypoesthesia (OR = 3.81, 95% CI: 1.32\u201011.00), constipation (OR = 2.43, 95% CI: 2.02\u20102.93), and dizziness (OR = 2.26, 95% CI: 1.72\u20102.98). Phentermine\/topiramate also reduced waist circumference, blood pressure, blood sugar levels, and lipid levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phentermine\/topiramate has considerable benefit in reducing body weight, and the efficacy was closely related to the dosage. However, it increased the risk of nervous system\u2010related adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23152","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T01:28:12Z","timestamp":1618622892000},"page":"985-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Efficacy and Safety of Phentermine\/Topiramate in Adults with Overweight or Obesity: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-7910","authenticated-orcid":false,"given":"Xiang\u2010Guo","family":"Lei","sequence":"first","affiliation":[{"name":"Geriatrics Department of Endocrinology and Metabolism The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio cerebrovascular Diseases Control and Prevention The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Clinical Research Center for Cardiocerebrovascular Diseases The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Qi","family":"Ruan","sequence":"additional","affiliation":[{"name":"School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Geriatrics Department of Endocrinology and Metabolism The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio cerebrovascular Diseases Control and Prevention The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Clinical Research Center for Cardiocerebrovascular Diseases The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Geriatrics Department of Endocrinology and Metabolism The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio cerebrovascular Diseases Control and Prevention The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Clinical Research Center for Cardiocerebrovascular Diseases The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67483-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.189702"},{"key":"e_1_2_9_6_1","first-page":"641","article-title":"The morbidity and mortality associated with overweight and obesity in adulthood: a systematic review","volume":"106","author":"Lenz M","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.03.107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-5-200509060-00013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb05201.x"},{"key":"e_1_2_9_10_1","unstructured":"Qsymia.Highlights of prescribing information.VIVUS Inc;2012. 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