{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:27:05Z","timestamp":1773199625025,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate microvascular differences in individuals with obesity at risk for developing cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional Netherlands Epidemiology of Obesity study, participant sublingual microcirculation was assessed with a newly developed GlycoCheck software (Microvascular Health Solutions Inc., Salt Lake City, Utah), which integrates red blood cell velocity within the smallest capillaries (4\u20107 \u00b5m) and feed vessels (&gt;10 \u00b5m). Framingham Risk Score was used to calculate 10\u2010year cardiovascular risk, divided into low\u2010, intermediate\u2010, and high\u2010risk groups. ANOVA was used to evaluate microvascular differences among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 813 participants were included. The high\u2010risk group (<jats:italic>n<\/jats:italic> = 168) was characterized by differences in the microvasculature compared with the low\u2010risk group (<jats:italic>n<\/jats:italic> = 392): the high\u2010risk group had a 49% reduction in the number of smallest capillaries and a 9.1\u2010\u00b5m\/s (95% CI: 5.2\u201012.9) higher red blood cell velocity in the feed vessels. No differences in velocity\u2010corrected perfused boundary regions were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was observed that, with adding red blood cell velocity to the software, sidestream dark field imaging is able to detect microcirculatory differences in a cohort of individuals with obesity at risk for developing cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23222","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T11:01:11Z","timestamp":1627902071000},"page":"1439-1444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microvascular differences in individuals with obesity at risk of developing cardiovascular disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Anouk I. M.","family":"van der Velden","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Einthoven Laboratory for Vascular and Regenerative Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-6026","authenticated-orcid":false,"given":"Bernard M.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Einthoven Laboratory for Vascular and Regenerative Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"de Mutsert","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"van der Vlag","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nijmegen Centre for Molecular Life Sciences Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ton J.","family":"Rabelink","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Einthoven Laboratory for Vascular and Regenerative Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Vink","sequence":"additional","affiliation":[{"name":"Department of Physiology Cardiovascular Research Institute Maastricht Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.191"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025404.78001.D8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019020192"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.07.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096477"},{"key":"e_1_2_9_7_1","first-page":"445","article-title":"Non\u2010invasive imaging of microcirculation: a technology review","volume":"7","author":"Eriksson S","year":"2014","journal-title":"Med Devices (Auckl)"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9801-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03520-w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680590895028"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129772.26647.6F"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.10.021"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.5.382"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08160813"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13236"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:15:06Z","timestamp":1693354506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/oby.23222"],"URL":"https:\/\/doi.org\/10.1002\/oby.23222","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"2021-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}