{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:09:59Z","timestamp":1777414199872,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies have unveiled a relationship between the severity of coronavirus disease 2019 (COVID\u201019) pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, and current smoking status) in critically ill patients with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted to intensive care units for COVID\u201019 in 21 centers (in Europe, Israel, and the United States) were enrolled in this study between February 19, 2020, and May 19, 2020. Primary and secondary outcomes were the need for invasive mechanical ventilation (IMV) and 28\u2010day mortality, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,461 patients were enrolled; the median (interquartile range) age was 64 years (40.9\u201072.0); 73.2% of patients were male; the median BMI was 28.1 kg\/m<jats:sup>2<\/jats:sup> (25.4\u201032.3); a total of 1,080 patients (73.9%) required IMV; and the 28\u2010day mortality estimate was 36.1% (95% CI: 33.0\u201039.5). An adjusted mixed logistic regression model showed a significant linear relationship between BMI and IMV: odds ratio = 1.27 (95% CI: 1.12\u20101.45) per 5 kg\/m<jats:sup>2<\/jats:sup>. An adjusted Cox proportional hazards regression model showed a significant association between BMI and mortality, which was increased only in obesity class III (\u226540; hazard ratio = 1.68 [95% CI: 1.06\u20102.64]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In critically ill COVID\u201019 patients, a linear association between BMI and the need for IMV, independent of other metabolic risk factors, and a nonlinear association between BMI and mortality risk were observed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23223","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T11:00:46Z","timestamp":1620558046000},"page":"1477-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["BMI and pneumonia outcomes in critically ill COVID\u201019 patients: An international multicenter study"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-4310","authenticated-orcid":false,"given":"Mikael","family":"Chetboun","sequence":"first","affiliation":[{"name":"Univ Lille Inserm Lille Pasteur Institute European Genomic Institute for Diabetes U1190 F\u201059000  Lille France"},{"name":"CHU Lille Centre Int\u00e9gr\u00e9 de l'Ob\u00e9sit\u00e9 F\u201059000  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-2028","authenticated-orcid":false,"given":"Violeta","family":"Raverdy","sequence":"additional","affiliation":[{"name":"Univ Lille Inserm Lille Pasteur Institute European Genomic Institute for Diabetes U1190 F\u201059000  Lille France"},{"name":"CHU Lille Centre Int\u00e9gr\u00e9 de l'Ob\u00e9sit\u00e9 F\u201059000  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"ULR 2694 \u2010 METRICS: Assessment of Health Technologies and Medical Practices Univ Lille CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Simonnet","sequence":"additional","affiliation":[{"name":"Department of Intensive Care CHU Lille Univ Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Wallet","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit Hospices Civils de Lyon Lyon Sud Hospital  Pierre\u2010B\u00e9nite France"},{"name":"Emerging Pathogens Laboratory\u2010M\u00e9rieux Foundation International Center for Infectious Disease Research Inserm U1111  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-2907","authenticated-orcid":false,"given":"Cyrielle","family":"Caussy","sequence":"additional","affiliation":[{"name":"Diabetes and Nutrition Department of Endocrinology Hospices Civils de Lyon Lyon Sud Hospital  Pierre\u2010B\u00e9nite France"},{"name":"CarMen Laboratory University of Lyon INRA INSA Claude Bernard Lyon 1 University Inserm  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-1670","authenticated-orcid":false,"given":"Massimo","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine Fondazione Policlinico Universitario A. 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