{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:17:47Z","timestamp":1790345867215,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["IT15608"],"award-info":[{"award-number":["IT15608"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","award":["MSFHR 16890"],"award-info":[{"award-number":["MSFHR 16890"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MSH\u2010141980"],"award-info":[{"award-number":["MSH\u2010141980"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to determine whether a Mediterranean\u2010style, ketogenic diet mobile health application (app) with breath acetone biofeedback is superior to a calorie\u2010restricted, low\u2010fat diet app in promoting weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>n<\/jats:italic>\n                      = 155) with overweight\/obesity (mean [SD]: age 41 [11] years, BMI = 34 [5] kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 71% female) were randomized to one of the interventions delivered entirely via app. Participants received a wireless scale and were instructed to take daily weight measurements. A third\u2010party laboratory collected blood samples at baseline and 12 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Weight loss at 12 weeks was greater in the ketogenic (\u22125.6 kg; 95% CI: \u22126.7 kg to \u22124.5 kg) compared with the low\u2010fat group (\u22122.5 kg; 95% CI: \u22123.6 kg to \u22121.4 kg) (between\u2010group difference: \u22123.1 kg; 95% CI: \u22124.6 kg to \u22121.5 kg;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Weight loss at 24 weeks indicated durability of the effect (between\u2010group difference: \u22125.5 kg; 95% CI: \u22128.3 kg to \u22122.8 kg;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Secondary\/exploratory outcomes of hemoglobin A1c and liver enzymes were improved to a greater extent in the ketogenic diet group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among adults with overweight\/obesity, a ketogenic diet app with breath acetone biofeedback was superior to a calorie\u2010restricted diet app at promoting weight loss in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23242","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T07:02:48Z","timestamp":1623654168000},"page":"1606-1614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-964X","authenticated-orcid":false,"given":"Kaja","family":"Falkenhain","sequence":"first","affiliation":[{"name":"School of Health and Exercise Sciences University of British Columbia Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"Locke","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences University of British Columbia Kelowna British Columbia Canada"},{"name":"Department of Kinesiology Brock University St. Catherines Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan A.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute University of California San Francisco San Francisco California USA"},{"name":"Eureka Research Platform San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Reitsma","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences University of British Columbia Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Health Evaluation and Outcome Sciences, School of Population and Public Health University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[{"name":"Centre for Health Evaluation and Outcome Sciences, School of Population and Public Health University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-5816","authenticated-orcid":false,"given":"Ethan J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-2008","authenticated-orcid":false,"given":"Jonathan P.","family":"Little","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences University of British Columbia Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.116"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945919888224"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2018.12.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2010.10.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21242"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2019.08.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2238"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.1.43"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2196\/19053"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200303"},{"key":"e_1_2_10_12_1","unstructured":"Keyto.The science behind Keyto part one \u2013 how the Keyto breath sensor works.https:\/\/getkeyto.com\/science\u2010behind\u2010keyto\u2010how\u2010the\u2010breath\u2010sensor\u2010works\/. Accessed May 8 2021."},{"key":"e_1_2_10_13_1","unstructured":"Weight Watcher's WW.SmartPoints: Starter Guide. Accessed May 8 2021.https:\/\/www.weightwatchers.com\/us\/how\u2010it\u2010works\/smartpoints"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2012.04.016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"issue":"3","key":"e_1_2_10_16_1","first-page":"141","article-title":"A simple method to assess exercise behavior in the community","volume":"10","author":"Godin G","year":"1985","journal-title":"Can J Appl Sport Sci"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515004699"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022207"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22389"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa350"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12744"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38833.411204.80"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022637"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6500"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225348"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031796"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.5.1146"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280532"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:44:06Z","timestamp":1692848646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/oby.23242"],"URL":"https:\/\/doi.org\/10.1002\/oby.23242","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"2021-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}