{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:16:53Z","timestamp":1784888213342,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107\u20102314\u2010B\u2010002\u2010195\u2010MY3"],"award-info":[{"award-number":["107\u20102314\u2010B\u2010002\u2010195\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity is associated with epigenetic age acceleration (EAA), resulting in an increased risk of many age\u2010related disorders. However, most studies have focused on the relationship of EAA with BMI. Whether any other obesity metric is more relevant to EAA remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, the methylation ages of 2,474 Taiwan Biobank (TWB) participants were calculated according to Levine\u2019s phenotypic age (PhenoAge) and Lu\u2019s GrimAge. Residuals from regressing methylation age on chronological age were used to quantify PhenoEAA and GrimEAA. Five obesity metrics were evaluated, namely BMI, body fat percentage, waist circumference, hip circumference, and waist\u2010hip ratio. Sex\u2010stratified EAA was regressed on each of the five obesity metrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For male individuals, an increase of one SD in waist\u2010hip ratio (0.06) was associated with a 0.602\u2010year PhenoEAA (<jats:italic>p<\/jats:italic> = 6.3E\u20106) and a 0.481\u2010year GrimEAA (<jats:italic>p<\/jats:italic> = 1.2E\u20108). For female individuals, every SD increase in BMI (3.7 kg\/m<jats:sup>2<\/jats:sup>) was associated with a 0.600\u2010year PhenoEAA (<jats:italic>p<\/jats:italic> = 3.3E\u20105) and a 0.305\u2010year GrimEAA (<jats:italic>p<\/jats:italic> = 3.1E\u20105).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u201cAbdominal obesity\u201d and \u201cgeneral obesity\u201d are significantly associated with male and female EAA, respectively. The prevention of abdominal obesity and general obesity is associated with a lower risk of EAA in men and women, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23255","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T12:13:24Z","timestamp":1630584804000},"page":"1731-1738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Associations of five obesity metrics with epigenetic age acceleration: Evidence from 2,474 Taiwan Biobank participants"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-4702","authenticated-orcid":false,"given":"Wan\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"},{"name":"Master of Public Health Degree Program College of Public Health National Taiwan University Taipei 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