{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:26:48Z","timestamp":1783535208983,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK117623"],"award-info":[{"award-number":["DK117623"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated, in a large pediatric population, whether magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis is associated with baseline or change over 1 year in body adiposity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional and prospective cohort analyses were conducted within the Adolescent Brain Cognitive Development Study. Study 1 included 169 children with usable baseline T2\u2010weighted MRI images and anthropometrics from baseline and 1\u2010year follow\u2010up study visits. Signal ratios compared T2 signal intensity in MBH and two reference regions (amygdala [AMY] and putamen) as a measure of MBH gliosis. Study 2 included a distinct group of 238 children with overweight or obesity to confirm initial findings in an independent sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Study 1, MBH\/AMY signal ratio was positively associated with BMI <jats:italic>z<\/jats:italic> score (<jats:italic>\u03b2<\/jats:italic> = 4.27, <jats:italic>p<\/jats:italic> &lt; 0.001). A significant interaction for the association of MBH\/AMY signal ratio with change in BMI <jats:italic>z<\/jats:italic> score suggested that relationships differed by baseline weight status. Study 2 found that higher MBH\/AMY signal ratios associated with an increase in BMI <jats:italic>z<\/jats:italic> score for children with overweight (<jats:italic>\u03b2<\/jats:italic> = 0.58, <jats:italic>p<\/jats:italic> = 0.01), but not those with obesity (<jats:italic>\u03b2<\/jats:italic> = 0.02, <jats:italic>p<\/jats:italic> = 0.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Greater evidence of hypothalamic gliosis by MRI is associated with baseline BMI <jats:italic>z<\/jats:italic> score and predicts adiposity gain in young children at risk of obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23286","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T07:09:05Z","timestamp":1636009745000},"page":"1770-1779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Greater radiologic evidence of hypothalamic gliosis predicts adiposity gain in children at risk for obesity"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-9499","authenticated-orcid":false,"given":"Leticia E.","family":"Sewaybricker","sequence":"first","affiliation":[{"name":"Department of Medicine University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Melhorn","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1013-0795","authenticated-orcid":false,"given":"Ellen A.","family":"Schur","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.1999.11904395"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-11-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104344"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00111"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59660"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21248"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22324"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12486"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12732"},{"key":"e_1_2_10_12_1","unstructured":"JerniganTL.2019.Adolescent Brain Cognitive Development Study (ABCD) National Institute of Mental Health Data Archive. 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