{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:22:01Z","timestamp":1790824921651,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 109 hospitalized COVID\u201019 patients in noncritical status were cross\u2010sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C\u2010reactive protein, ferritin, D\u2010dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow\u2010mediated dilation (FMD) method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: \u22120.26 to \u22120.11; <jats:italic>p<\/jats:italic> &lt; 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: \u22121.77 to \u22120.29; <jats:italic>p<\/jats:italic> = 0.007) and blood levels of creatinine (95% CI: \u22121.99 to \u22120.16; <jats:italic>p<\/jats:italic> = 0.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID\u201019 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23311","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T14:10:32Z","timestamp":1632406232000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Determinants of endothelial dysfunction in noncritically ill hospitalized COVID\u201019 patients: A cross\u2010sectional study"],"prefix":"10.1002","volume":"30","author":[{"given":"Alessandro Domingues","family":"Heubel","sequence":"first","affiliation":[{"name":"Cardiopulmonary Physiotherapy Laboratory Department of Physical Therapy Federal University of S\u00e3o Carlos S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane Aparecida","family":"Viana","sequence":"additional","affiliation":[{"name":"Exercise and Chronic 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S\u00e3o Carlos S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Yudi Orikassa","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Exercise and Chronic Disease Research Laboratory Department of Physical Education School of Sciences S\u00e3o Paulo State University Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Camila","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Universidad Industrial de Santander Bucaramanga Santander Colombia"},{"name":"Department of Gerontology Federal University of S\u00e3o Carlos S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Sacred Heart University Center Bauru S\u00e3o Paulo 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