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Excess pancreatic fat may disturb insulin secretion and relate to hepatic fat. Associations between pancreatic fat fraction (PFF) and metabolic measures in PCOS were unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This secondary analysis included 113 sedentary, nondiabetic adolescent girls (age = 15.4 [1.9] years), with or without PCOS and BMI \u2265 90th percentile. Participants underwent fasting labs, oral glucose tolerance tests, and magnetic resonance imaging for hepatic fat fraction (HFF) and PFF. Groups were categorized by PFF (above or below the median of 2.18%) and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visceral fat and HFF were elevated in individuals with PCOS versus control individuals, but PFF was similar. PFF did not correlate with serum androgens. Higher and lower PFF groups had similar HFF, with no correlation between PFF and HFF, although hepatic steatosis was more common in those with higher PFF (\u22655.0% HFF; 60% vs. 36%; <jats:italic>p<\/jats:italic> = 0.014). The higher PFF group had higher fasting insulin (<jats:italic>p<\/jats:italic> = 0.026), fasting insulin resistance (homeostatic model assessment of insulin resistance, <jats:italic>p<\/jats:italic> = 0.032; 1\/fasting insulin, <jats:italic>p<\/jats:italic> = 0.028), free fatty acids (<jats:italic>p<\/jats:italic> = 0.034), and triglycerides (<jats:italic>p<\/jats:italic> = 0.004) compared with those with lower PFF. \u03b2\u2010Cell function and insulin sensitivity were similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither PCOS status nor androgens related to PFF. However, fasting insulin and postprandial lipids were worse with higher PFF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23317","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T19:32:36Z","timestamp":1640115156000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-1963","authenticated-orcid":false,"given":"Meredith A.","family":"Ware","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics School of Medicine, University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Modern Human Anatomy University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Rocky Vista 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