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However, greater weight loss may be required to achieve improvements in or remission of certain weight\u2010related complications. Therefore, this study reviewed the effect of large weight loss (\u226510%). Most studies reporting large weight loss and relevant outcomes used bariatric surgery or lifestyle modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Benefits of large weight loss were observed in patients with various overweight\u2010 or obesity\u2010related complications, including improvements in comorbidities such as type 2 diabetes and hypertension. Improvements in glucose metabolism and cardiovascular risk factors were observed in patients who achieved large weight loss through lifestyle interventions or pharmacotherapy (phentermine\/topiramate 15\/92 mg once daily or subcutaneous semaglutide 2.4 mg once weekly). Other benefits associated with large weight loss included reduced cancer risk and improvements in knee osteoarthritis, sleep apnea, fertility\u2010related end points, and health\u2010related quality of life. While costly, bariatric surgery is currently the most cost\u2010effective intervention, although most weight\u2010management programs are deemed cost\u2010effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, large weight loss has a major beneficial impact on overweight\u2010 and obesity\u2010related complications. Large weight loss should be the main treatment target when modest weight loss has had insufficient effects on obesity\u2010related complications and for patients with severe obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23371","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T14:41:02Z","timestamp":1648219262000},"page":"802-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Benefits of weight loss of 10% or more in patients with overweight or obesity: A review"],"prefix":"10.1002","volume":"30","author":[{"given":"Abd A.","family":"Tahrani","sequence":"first","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-1283","authenticated-orcid":false,"given":"John","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults\u2010the evidence report. 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