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After 16 weeks of treatment, changes in anthropometric parameters, estrous cycle, hormone profiles, ovarian pathology, and gut microbiota and short\u2010\/medium\u2010chain fatty acids in colon contents were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Constant light exposure aggravated PCOS\u2010like phenotypes in HFD\u2010fed rats, such as hyperandrogenism, disrupted estrous cycle, and polycystic ovaries. Additionally, constant light exposure and an HFD synergized to decrease \u03b1\u2010diversity of gut microbiota, create a reduced abundance of\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      genus, and create an increased abundance of Firmicutes and the Firmicutes\/Bacteroidetes ratio. In HFD\u2010fed rats, the group with constant light exposure had an increase in propionate acid and a decrease in total medium\u2010chain fatty acids in colon contents compared with the standard light\u2010dark cycle group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Constant light exposure causes gut dysbiosis, alters production of short\u2010 and medium\u2010chain fatty acids, and aggravates PCOS\u2010like traits in HFD\u2010fed rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23380","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T02:09:12Z","timestamp":1644199752000},"page":"694-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Constant light exposure alters gut microbiota and short\u2010\/medium\u2010chain fatty 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