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Lomitapide was administered by gavage (1 mg\/kg\/d) during the last 2 weeks of high\u2010fat feeding. Body weight, blood glucose, body composition, and lipid profile were determined. Vascular function and endothelial function markers were studied in the aorta and mesenteric resistance arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lomitapide treatment reduced body weight in mice with obesity. Blood glucose, percentage of fat mass, total cholesterol, and low\u2010density lipoprotein levels were significantly reduced, and the percentage of lean mass was significantly increased after lomitapide treatment. The vascular response to sodium nitroprusside in the aorta and mesenteric arteries was similar among groups. However, the vascular response to acetylcholine was improved in the treated group. This was associated with decreased levels of vascular endoplasmic reticulum stress, inflammation, and oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with lomitapide attenuated the increase in body weight in mice with obesity and restored the lipid profile and vascular function. These effects were accompanied by a decrease in inflammation and oxidative stress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23389","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T04:09:55Z","timestamp":1646626195000},"page":"893-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity"],"prefix":"10.1002","volume":"30","author":[{"given":"Undral","family":"Munkhsaikhan","sequence":"first","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center  Memphis Tennessee 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