{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:44:01Z","timestamp":1747151041724,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Switching from tenofovir disoproxil fumarate (TDF)\u2010 to tenofovir alafenamide (TAF)\u2010containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes and their association with TAF remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort evaluated metabolic changes in virologically suppressed patients with HIV infection who switched from TDF to TAF without switching other antiretroviral therapy medications. Adult patients on TDF and with no HIV viral load values &gt;200 copies\/mL for \u22652\u2009years prior to and following a TAF switch were included. Weight and other variables were collected for 2\u2009years before and after the switch. Longitudinal linear mixed\u2010effects models evaluated changes at 1 and 2\u2009years after the switch.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the unadjusted analysis, there were increases in weight, BMI, total cholesterol, low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, triglycerides, systolic blood pressure, fasting glucose, and atherosclerotic cardiovascular disease risk scores 2\u2009years after switching to TAF (each <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.03). However, only increases in total and low\u2010density lipoprotein cholesterol were associated with TAF and were significantly different from expected changes predicted in the adjusted longitudinal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite observing significant unadjusted metabolic changes after switching to TAF, only changes in cholesterol were associated with TAF and were different from changes expected in time\u2010trend adjusted models.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23443","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T14:41:15Z","timestamp":1654699275000},"page":"1197-1204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Weight changes in patients with sustained viral suppression switching tenofovir disoproxil fumarate to tenofovir alafenamide"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-0973","authenticated-orcid":false,"given":"Jason J.","family":"Schafer","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Jefferson College of Pharmacy Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matty","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciara","family":"Walshe","sequence":"additional","affiliation":[{"name":"Jefferson College of Pharmacy Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Cerankowski","sequence":"additional","affiliation":[{"name":"Jefferson College of Pharmacy Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Shimada","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Division of Biostatistics Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-1151","authenticated-orcid":false,"given":"Scott W.","family":"Keith","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Division of Biostatistics Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(16)00024-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00348-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000908"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000225"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000618"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz414"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz360.410"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002496"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1227-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab444"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-4853"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25702"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ192"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2348"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0234"},{"key":"e_1_2_8_17_1","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents.Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services. Published June 3 2021. Accessed September 3 2021.https:\/\/clinicalinfo.hiv.gov\/sites\/default\/files\/guidelines\/documents\/guidelines-adult-adolescent-arv.pdf"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_2_8_19_1","first-page":"e1082","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"139","author":"Grundy SM","year":"2019","journal-title":"Circulation"},{"volume-title":"A Practical Guide to Splines","year":"2001","author":"Boor C","key":"e_1_2_8_20_1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476592"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902824"},{"key":"e_1_2_8_23_1","volume":"8","author":"Shah S","year":"2021","journal-title":"Open Forum Infect Dis"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T09:54:24Z","timestamp":1692611664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/oby.23443"],"URL":"https:\/\/doi.org\/10.1002\/oby.23443","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"type":"print","value":"1930-7381"},{"type":"electronic","value":"1930-739X"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2022-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}