{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:12:13Z","timestamp":1789053133357,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A2B4008673"],"award-info":[{"award-number":["2017R1A2B4008673"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1071570"],"award-info":[{"award-number":["2020R1F1A1071570"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B03030666"],"award-info":[{"award-number":["2017R1D1A1B03030666"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Leukocyte cell\u2010derived chemotaxin 2 (LECT2) is an obesity\u2010upregulated hepatokine inducing skeletal muscle insulin resistance. The study's aim was to explore whether LECT2 is expressed in human adipose tissue and whether the expression is dysregulated during obesity and associated with obesity\u2010related metabolic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study measured metabolic parameters, serum LECT2, and expression of <jats:italic>LECT2<\/jats:italic> and <jats:italic>CD209<\/jats:italic>, a gene encoding a putative receptor for LECT2, in abdominal subcutaneous and visceral adipose tissues in women with obesity (with or without type 2 diabetes) and women with normal weight. The expression\/secretion of LECT2 and its putative effects were assessed in human adipocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adipose tissue <jats:italic>LECT2<\/jats:italic> mRNA and serum LECT2 were higher in women with obesity and were significantly correlated with parameters related to insulin resistance. <jats:italic>LECT2<\/jats:italic> was mainly expressed by adipocytes. Both <jats:italic>LECT2<\/jats:italic> and <jats:italic>CD209<\/jats:italic> expression was higher in adipocytes from women with obesity. Incubating adipocytes with substances mimicking the microenvironment of obesity adipose tissue increased LECT2 expression\/secretion. LECT2 treatment of adipocytes suppressed insulin\u2010stimulated Akt phosphorylation; it reduced adiponectin (<jats:italic>ADIPOQ)<\/jats:italic> and increased leptin (<jats:italic>LEP)<\/jats:italic> expression in a CD209\u2010dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that <jats:italic>LECT2<\/jats:italic> expression in adipose tissue is high in patients with obesity and associated with insulin resistance and suggests that adipocyte\u2010derived LECT2 may contribute to adipose tissue dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23445","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T08:47:45Z","timestamp":1655714865000},"page":"1430-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Adipose tissue LECT2 expression is associated with obesity and insulin resistance in <scp>K<\/scp>orean women"],"prefix":"10.1002","volume":"30","author":[{"given":"Jimin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"},{"name":"Brexogen Research Center Brexogen Inc.  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"},{"name":"Brexogen Research Center Brexogen Inc.  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donguk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"},{"name":"Department of Food and Nutrition, College of Health Science The University of Suwon  Hwaseong\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ji","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Ulsan College of Medicine  Seoul South Korea"},{"name":"Department of Clinical Epidemiology and Biostatistics ASAN Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hyeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Pio","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Inha University School of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-2401","authenticated-orcid":false,"given":"Hye Soon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9735-3739","authenticated-orcid":false,"given":"Yoonseok","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of General Surgery Inha University School of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7350-5534","authenticated-orcid":false,"given":"Yeon Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3283514e13"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00052"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2391"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319451"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102912"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(96)02572-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(97)00181-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7095"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12469"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0728"},{"key":"e_1_2_8_12_1","first-page":"276","article-title":"Increased serum leukocyte cell\u2010derived chemotaxin 2 (LECT2) levels in obesity and fatty liver","volume":"7","author":"Okumura A","year":"2013","journal-title":"Biosci Trends"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173310"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174717"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010354"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.11.038"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103160"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002829"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.01.020"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03855.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121466"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12719"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.06.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0267"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab780"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz066"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32419-w"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.07.002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4409"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30609"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-169-1_5"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.08.098"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0818"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70192-x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5198"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20286"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15048889"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T09:16:12Z","timestamp":1692868572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/oby.23445"],"URL":"https:\/\/doi.org\/10.1002\/oby.23445","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"assertion":[{"value":"2022-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}