{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:29:37Z","timestamp":1790562577416,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060246"],"award-info":[{"award-number":["82060246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to recapitulate the change trajectory of postoperative weight and investigate the association between postoperative hypothalamic damage and weight gain and hypothalamic obesity (HO) in patients with adult\u2010onset craniopharyngioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 96 patients with surgically treated primary adult\u2010onset craniopharyngioma were retrospectively analyzed. The association between postoperative hypothalamic damage based on magnetic resonance images or endoscopic observation and postoperative weight gain and HO was determined by multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven (49.0%) patients and 18 (18.8%) patients experienced clinically meaningful weight gain (\u22655%) and HO at last follow\u2010up, respectively. Postoperative weight significantly increased during the first 6\u00a0months following surgery, followed by stabilization. Both grade 2 postoperative hypothalamus damage, as evaluated by the magnetic resonance imaging classification system of M\u00fcller et al., and higher scores based on the Roth et al. hypothalamic lesion score were significantly associated with postoperative weight gain of \u22655% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and with HO (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). Additionally, bilateral hypothalamic injury as evaluated by the Hong et al. hypothalamic injury pattern based on endoscopic observation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) could predict postoperative weight gain \u22655%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant postoperative weight gain is common in patients with adult\u2010onset craniopharyngioma. Postoperative hypothalamic damage can predict clinically meaningful weight gain and HO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23447","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T07:09:28Z","timestamp":1655363368000},"page":"1357-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Postoperative hypothalamic damage predicts postoperative weight gain in patients with adult\u2010onset craniopharyngioma"],"prefix":"10.1002","volume":"30","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Nanchang University  Nanchang 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