{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:52:23Z","timestamp":1792180343653,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["UG3OD023349"],"award-info":[{"award-number":["UG3OD023349"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K99 HD100593"],"award-info":[{"award-number":["K99 HD100593"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD060628"],"award-info":[{"award-number":["R01 HD060628"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00HD096109"],"award-info":[{"award-number":["R00HD096109"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R21 DK118578"],"award-info":[{"award-number":["R21 DK118578"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH091351"],"award-info":[{"award-number":["R01 MH091351"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study tested\u00a0the hypothesis, in a prospective cohort study design, that maternal saturated free fatty acid (sFFA) concentration during pregnancy is prospectively associated with offspring (newborn) hypothalamic (HTH) microstructure and to explore the functional relevance of this association with respect to early\u2010childhood body fat percentage (BF%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In <jats:italic>N<\/jats:italic> =\u200994 healthy newborns (born mean 39.3 [SD 1.5] weeks gestation), diffusion\u2010weighted magnetic resonance imaging was performed shortly after birth (25.3 [12.5] postnatal days), and a subgroup (<jats:italic>n<\/jats:italic> =\u200937) underwent a dual\u2010energy x\u2010ray absorptiometry scan in early childhood (4.7 [SD 0.7] years). Maternal sFFA concentration during pregnancy was quantified in fasting blood samples via liquid chromatography\u2010mass spectrometry. Infant HTH microstructural integrity was characterized using mean diffusivity (MD). Multiple linear regression was used to test the association between maternal sFFA and HTH MD, accounting for newborn sex, age at scan, mean white matter MD, and image quality. Multiple linear regression models also tested the association between HTH MD and early\u2010childhood BF%, accounting for breastfeeding status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal sFFA during pregnancy accounted for 8.3% of the variation in newborn HTH MD (\u03b2\u2010std\u00a0=\u00a00.25; <jats:italic>p<\/jats:italic> =\u20090.006). Furthermore, newborn HTH MD prospectively accounted for 15% of the variation in early\u2010childhood BF% (\u03b2\u2010std\u00a0=\u00a00.32; <jats:italic>p<\/jats:italic> =\u20090.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that maternal overnutrition during pregnancy may influence the development of the fetal hypothalamus, which, in turn, may have clinical relevance for childhood obesity risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23452","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T05:47:45Z","timestamp":1656913665000},"page":"1462-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-7750","authenticated-orcid":false,"given":"Jerod M.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Development, Health and Disease Research Program University of California, Irvine  Irvine California USA"},{"name":"Department of Pediatrics University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Gyllenhammer","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California, Irvine  Irvine California USA"},{"name":"Department of Pediatrics University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California, Irvine  Irvine California USA"},{"name":"University of California, Irvine Susan Samueli Integrative Health Institute College of Health Sciences, University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8590-5057","authenticated-orcid":false,"given":"Thomas G.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Nutritional Medicine, Department of Pediatrics, Dr von Hauner Children's Hospital Ludwig\u2010Maximillian University Munich, University Hospitals  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Entringer","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California, Irvine  Irvine California USA"},{"name":"Department of Pediatrics University of California, Irvine  Irvine California USA"},{"name":"Institute of Medical Psychology Charit\u00e9 University Hospital Berlin, corporate member of Free University of Berlin, Humboldt\u2010University of Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathik D.","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California, Irvine  Irvine California USA"},{"name":"Department of Pediatrics University of California, Irvine  Irvine California USA"},{"name":"Department of Psychiatry and Human Behavior University of California, Irvine  Irvine California USA"},{"name":"Department of Obstetrics and Gynecology University of California, Irvine  Irvine California USA"},{"name":"Department of Epidemiology University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Buss","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California, Irvine  Irvine California USA"},{"name":"Department of Pediatrics University of California, Irvine  Irvine California USA"},{"name":"Institute of Medical Psychology Charit\u00e9 University Hospital Berlin, corporate member of Free University of Berlin, Humboldt\u2010University of Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12061"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7283.377"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.167254"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00111"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.426"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-019-0451-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.043"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59660"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2016.06.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.105254"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00126"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2642-08.2008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2015.08.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101079"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.06.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001230"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01036"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0425"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074927"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.153"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2760-08.2009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","unstructured":"ParkS JangA BouretSG.Maternal obesity\u2010induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring. PLoSBiol2020;18:e3000296.10.1371\/journal.pbio.3000296","DOI":"10.1371\/journal.pbio.3000296"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094594"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2581"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53578-4"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79289-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.04.020"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309753"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145794"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac202602u"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600964"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.064"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.63"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103238118"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2016.12.004"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.101"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-014-0129-4"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0210"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13392"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3803"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05170-z"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30013-X"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T09:16:19Z","timestamp":1692868579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/oby.23452"],"URL":"https:\/\/doi.org\/10.1002\/oby.23452","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2021-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}