{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:44:05Z","timestamp":1747151045609,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK\u2010094406","U01DK\u2010094430","U01DK\u2010094431","U01DK\u2010094438","U01DK\u2010094467","P30DK\u2010017047","P30DK\u2010020595","P30DK\u2010045735","P30DK\u2010097512","UL1TR\u2010000430","UL1TR\u2010001082","UL1TR\u2010001108","UL1TR\u2010001855","UL1TR\u2010001857","UL1TR\u2010001858","UL1TR\u2010001863"],"award-info":[{"award-number":["U01DK\u2010094406","U01DK\u2010094430","U01DK\u2010094431","U01DK\u2010094438","U01DK\u2010094467","P30DK\u2010017047","P30DK\u2010020595","P30DK\u2010045735","P30DK\u2010097512","UL1TR\u2010000430","UL1TR\u2010001082","UL1TR\u2010001108","UL1TR\u2010001855","UL1TR\u2010001857","UL1TR\u2010001858","UL1TR\u2010001863"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The extent to which weight loss contributes to increases in insulin sensitivity (IS) and \u03b2\u2010cell function after surgical or medical intervention has not been directly compared in individuals with impaired glucose tolerance or newly diagnosed type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Restoring Insulin Secretion (RISE) Study included adults in the Beta\u2010Cell Restoration Through Fat Mitigation Study (<jats:italic>n<\/jats:italic>\u00a0=\u00a088 randomized to laparoscopic gastric banding or metformin [MET]) and the Adult Medication Study (<jats:italic>n<\/jats:italic>\u00a0=\u00a0267 randomized to placebo, MET, insulin glargine\/MET, or liraglutide\u2009+\u2009MET [L\u2009+\u2009M]). IS and \u03b2\u2010cell responses were measured at baseline and after 12 months by modeling of oral glucose tolerance tests and during arginine\u2010stimulated hyperglycemic clamps. Linear regression models assessed differences between and within treatments over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMI decreased in all treatment groups, except placebo, at 12 months. IS increased in all arms except placebo and was inversely correlated with changes in BMI. L\u2009+\u2009M was the only treatment arm that enhanced multiple measures of \u03b2\u2010cell function independent of weight loss. Insulin secretion decreased in the laparoscopic gastric banding arm proportional to increases in IS, with no net benefit on \u03b2\u2010cell function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reducing demand on the \u03b2\u2010cell by improving IS through weight loss does not reverse \u03b2\u2010cell dysfunction. L\u2009+\u2009M was the only treatment that enhanced \u03b2\u2010cell function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23475","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T09:16:41Z","timestamp":1658913401000},"page":"1579-1588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Weight loss and \u03b2\u2010cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial"],"prefix":"10.1002","volume":"30","author":[{"given":"Kristina M.","family":"Utzschneider","sequence":"first","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Ehrmann","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silva A.","family":"Arslanian","sequence":"additional","affiliation":[{"name":"UPMC Children's Hospital of Pittsburgh University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Barengolts","sequence":"additional","affiliation":[{"name":"Jesse Brown VA Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Caprio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Edelstein","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara S.","family":"Hannon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E.","family":"Kahn","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kozedub","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieren J.","family":"Mather","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen J.","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Sam","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tripputi","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-1268","authenticated-orcid":false,"given":"Anny H.","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-8407","authenticated-orcid":false,"given":"Laure","family":"El ghormli","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The RISE Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Centers for Disease Control and Prevention. Adult obesity facts. Updated May 17 2022. Accessed June 7 2021.https:\/\/www.cdc.gov\/obesity\/data\/adult.html"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.04.012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2017.31"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05245-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.2.358"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1376"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1299"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61375-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0589"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00564"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00235"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1879"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1662"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0556"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0243"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.41.3.368"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00093.2002"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00946.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0244"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.3.539"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0371"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0714"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0893"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1797"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0291"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0918"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:17:48Z","timestamp":1692839868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/oby.23475"],"URL":"https:\/\/doi.org\/10.1002\/oby.23475","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"type":"print","value":"1930-7381"},{"type":"electronic","value":"1930-739X"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"assertion":[{"value":"2022-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}