{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:23:52Z","timestamp":1771640632729,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["16\/RI\/3399"],"award-info":[{"award-number":["16\/RI\/3399"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["20\/COV\/8549"],"award-info":[{"award-number":["20\/COV\/8549"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["20\/COV\/0305"],"award-info":[{"award-number":["20\/COV\/0305"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014364","name":"National Children's Research Centre","doi-asserted-by":"publisher","award":["PRPG\/C\/18\/323"],"award-info":[{"award-number":["PRPG\/C\/18\/323"]}],"id":[{"id":"10.13039\/100014364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity is a major risk factor for severe disease in COVID\u201019, with increased hospitalization, intensive care unit admission, and mortality. This increased impact of COVID\u201019 in people with obesity (PWO) is likely driven, in part, by the well\u2010described obesity\u2010induced immune dysregulation. Obesity has also been associated with impaired immune memory in many settings, including weakened responses to hepatitis B, tetanus, rabies, and influenza vaccination. Recently, it was reported that PWO who have COVID\u201019 have reduced IgG antibody titers with defective neutralizing capabilities. However, it remains unknown whether PWO generate durable T cell immunity to SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study investigated SARS\u2010CoV\u20102\u2010specific T cell responses in a cohort of 40 patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a020 PWO and <jats:italic>n<\/jats:italic>\u00a0=\u00a020 matched control individuals) who had recovered from COVID\u201019. T cell (CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>) cytokine responses (IFN\u03b3, TNF\u03b1) to SARS\u2010CoV\u20102 peptide pools (spike, membrane) were determined using multicolor flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circulating T cells specific for SARS\u2010CoV\u20102 were readily detected in the total cohort. PWO displayed comparable levels of SARS\u2010CoV\u20102 spike\u2010 and membrane\u2010specific T cells, with both T cell subsets responding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data indicate that PWO who survive COVID\u201019 generate robust and durable SARS\u2010CoV\u20102\u2010specific T cell immunity that is equivalent to that seen in those without obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23526","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T11:18:57Z","timestamp":1656501537000},"page":"1927-1931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Individuals with obesity who survive <scp>SARS\u2010CoV<\/scp>\u20102 infection have preserved antigen\u2010specific T cell frequencies"],"prefix":"10.1002","volume":"30","author":[{"given":"Neil E.","family":"Wrigley Kelly","sequence":"first","affiliation":[{"name":"St Vincent's University Hospital &amp; University College Dublin  Dublin Ireland"},{"name":"Kathleen Lonsdale Institute for Human Health Research Maynooth University  Maynooth Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Kenny","sequence":"additional","affiliation":[{"name":"St Vincent's University Hospital &amp; University College Dublin  Dublin Ireland"},{"name":"Centre for Experimental Pathogen Host Research, School of Medicine University College Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-9519","authenticated-orcid":false,"given":"F\u00e9aron C.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Kathleen Lonsdale Institute for Human Health Research Maynooth University  Maynooth Ireland"},{"name":"National Children's Research Centre  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Garcia\u2010Leon","sequence":"additional","affiliation":[{"name":"Centre for Experimental Pathogen Host Research, School of Medicine University College Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor","family":"De Barra","sequence":"additional","affiliation":[{"name":"Kathleen Lonsdale Institute for Human Health Research Maynooth University  Maynooth Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W. G.","family":"Mallon","sequence":"additional","affiliation":[{"name":"St Vincent's University Hospital &amp; University College Dublin  Dublin Ireland"},{"name":"Centre for Experimental Pathogen Host Research, School of Medicine University College Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-230X","authenticated-orcid":false,"given":"Andrew E.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Kathleen Lonsdale Institute for Human Health Research Maynooth University  Maynooth Ireland"},{"name":"National Children's Research Centre  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donal","family":"O'Shea","sequence":"additional","affiliation":[{"name":"St Vincent's University Hospital &amp; University College Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13128"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00089-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.208"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.12.019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605223142119"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.017"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.038"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024377\u20101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4063"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103743"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13185"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201706-447AW"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02906.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600597326"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-01016-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13112235"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1592"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl5344"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.01.020"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:21:39Z","timestamp":1692627699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/oby.23526"],"URL":"https:\/\/doi.org\/10.1002\/oby.23526","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2022-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}