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The Institute of Medicine developed guidelines for gestational weight gain (GWG) targets for women with overweight\/obesity, but it is unclear whether exceeding these targets has adverse effects on maternal glucose metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Insulin sensitivity (assessed using the Matsuda Insulin Sensitivity Index), \u03b2\u2010cell function (assessed as insulin secretion rate in relation to plasma glucose), and plasma insulin clearance rate were evaluated using a frequently sampled oral glucose tolerance test at 15 and 35\u2009weeks of gestation in 184 socioeconomically disadvantaged African American women with overweight\/obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Insulin sensitivity decreased, whereas \u03b2\u2010cell function and insulin clearance increased from 15 to 35\u2009weeks of gestation in the entire group. Compared with women who achieved the recommended GWG, excessive GWG was associated with a greater decrease in insulin sensitivity between 15 and 35\u2009weeks. \u03b2\u2010cell function and plasma insulin clearance were not affected by excessive GWG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data demonstrate that gaining more weight during pregnancy than recommended by the Institute of Medicine is associated with functional effects on glucose metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23533","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T17:34:54Z","timestamp":1663954494000},"page":"2014-2022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight\/obesity"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-7623","authenticated-orcid":false,"given":"William Todd","family":"Cade","sequence":"first","affiliation":[{"name":"Program in Physical Therapy Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"Doctor of Physical Therapy Division, Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Mittendorfer","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Haire\u2010Joshu","sequence":"additional","affiliation":[{"name":"Brown School Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison G.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Washington University in St. Louis School of Medicine  St. Louis Missouri USA"},{"name":"Department of Women's Health Dell Medical School, The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-4845","authenticated-orcid":false,"given":"Richard I.","family":"Stein","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth 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