{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:12:45Z","timestamp":1780330365718,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>It remains elusive whether prediagnostic BMI trajectory is associated with pancreatic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study investigated this question among 145,489 participants who gave rise to 696 incident cases of pancreatic cancer over a median follow\u2010up of 12\u2009years in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. At baseline, participants were asked to recall their weight at ages 20, 50, and 55 to 74\u2009years (at enrollment), as well as their height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At age 50\u2009years, people with obesity had a significantly increased risk of pancreatic cancer compared with those with a normal weight after adjustment for confounders (hazard ratio [95% CI]: 1.27 [1.01\u20101.60]). Individuals who had overweight at age 20\u2009years experienced a marginally significant elevated risk of pancreatic cancer (hazard ratio [95% CI]: 1.22 [0.99\u20101.50]). Compared with individuals who maintained a steady normal weight during follow\u2010up, no significantly altered risk of pancreatic cancer was observed for those whose weight status changed from normal weight to overweight, from normal weight to obesity, and from overweight to obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study revealed that prediagnostic adulthood BMI trajectory was not associated with pancreatic cancer risk, but overweight at young adulthood and obesity at middle adulthood may confer an elevated risk of this malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23550","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T04:45:01Z","timestamp":1664167501000},"page":"2275-2285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prediagnostic BMI trajectories in relation to pancreatic cancer risk in the<scp>Prostate, Lung, Colorectal, and Ovarian<\/scp>Cancer Screening Trial"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-2095","authenticated-orcid":false,"given":"Margaret","family":"Hoyt","sequence":"first","affiliation":[{"name":"Department of Epidemiology Richard M. Fairbanks School of Public Health, Indiana University\u2013Purdue University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Richard M. Fairbanks School of Public Health, Indiana University\u2013Purdue University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science Richard M. Fairbanks School of Public Health and School of Medicine, Indiana University\u2013Purdue University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelynn","family":"O'Palka","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics School of Health and Human Sciences, Indiana University\u2013Purdue University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-2388","authenticated-orcid":false,"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Richard M. Fairbanks School of Public Health, Indiana University\u2013Purdue University Indianapolis Indiana USA"},{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University\u2013Purdue University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30974-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_9_4_1","first-page":"485","article-title":"Pancreatic cancer: diagnosis and management","volume":"73","author":"Freelove R","year":"2006","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319414"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3060"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20778"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.080708.082713"},{"key":"e_1_2_9_9_1","article-title":"Prevalence of obesity among adults and youth: United States, 2015\u20102016","author":"Hales CM","year":"2017","journal-title":"NCHS Data Brief"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601140"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5402\/2013\/680536"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22535"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.058123"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002081"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29981"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt281"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.29"},{"key":"e_1_2_9_18_1","unstructured":"United States Department of Health and Human Services.PLCO\u2010404: Interaction of Calcium Intake and Obesity on Pancreatic Cancer in the PLCO Trial: Data Dictionary. United States Department of Health and Human Services; 2018.https:\/\/cdas.cancer.gov\/approved-projects\/1945\/"},{"key":"e_1_2_9_19_1","unstructured":"WeirCB JanA.BMI Classification Percentile and Cut off Points. StatPearls Publishing;2022.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK541070\/"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124106292364"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124101029003005"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.63"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9002-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-019-00953-3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-019-01197-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1136\/jech-2017-208895","article-title":"Young adulthood and adulthood adiposity in relation to incidence of pancreatic cancer: a prospective study of 0.5 million Chinese adults and a meta\u2010analysis","volume":"71","author":"Pang Y","year":"2017","journal-title":"J Epidemiol Community Health"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25959"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20160193"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.886"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30187"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u20106627\u20108"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0014-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0301"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2015.1274"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(03)00071-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199501000-00012"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30019-X"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv355"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-5-199503010-00002"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.16.1523"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18859"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T16:26:49Z","timestamp":1728059209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/oby.23550"],"URL":"https:\/\/doi.org\/10.1002\/oby.23550","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,25]]},"assertion":[{"value":"2022-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}