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Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal\u2010R) is the most common approach to treating obesity, yet clinically meaningful weight loss is elusive owing to waning adherence. Time\u2010restricted eating (TRE) consists of consuming foods within a specified time frame, creating a natural calorie deficit. TRE in animals shows cancer protective effects. In humans, TRE is safe and acceptable among adults with obesity, producing ~3% to 5% weight loss and reductions in oxidative stress and insulin resistance. However, TRE has not been tested rigorously for CRC preventive effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors describe a 12\u2010month randomized controlled trial of 8\u2010hour TRE (ad libitum 12 PM\u20108 PM), Cal\u2010R (25% restriction daily), or Control among 255 adults at increased risk for CRC and with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Effects on the following will be examined: 1) body weight, body composition, and adherence; 2) circulating metabolic, inflammation, and oxidative stress biomarkers; 3) colonic mucosal gene expression profiles and tissue microenvironment; and 4) maintenance of benefits on body weight\/composition and CRC risk markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study will examine efficacious lifestyle strategies to treat obesity and reduce CRC risk among individuals with obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23579","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:37:08Z","timestamp":1667360228000},"page":"2376-2385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The basis and design for time\u2010restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (<scp>TRE\u2010CRC<\/scp> trial)"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-8892","authenticated-orcid":false,"given":"Kelsey","family":"Gabel","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois Chicago  Chicago Illinois USA"},{"name":"University of Illinois Cancer Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian 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