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Research investigating epigenetic mechanisms related to obesity and obesity\u2010associated conditions has identified differences that may contribute to cellular dysregulation that accelerates the development of disease. However, few studies include Black women, who experience the highest incidence of obesity and early onset of cardiometabolic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The association of BMI with epigenome\u2010wide DNA methylation (DNAm) was examined using the 850K Illumina EPIC BeadChip in two Black populations (Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure [InterGEN], <jats:italic>n<\/jats:italic>\u00a0=\u00a0239; and The Genetic Epidemiology Network of Arteriopathy [GENOA] study, <jats:italic>n<\/jats:italic>\u00a0=\u00a0961) using linear mixed\u2010effects regression models adjusted for batch effects, cell type heterogeneity, population stratification, and confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cross\u2010sectional analysis of the InterGEN discovery cohort identified 28 DNAm sites significantly associated with BMI, 24 of which had not been previously reported. Of these, 17 were replicated using the GENOA study. In addition, a meta\u2010analysis, including both the InterGEN and GENOA cohorts, identified 658 DNAm sites associated with BMI with false discovery rate\u2009&lt;\u20090.05. In a meta\u2010analysis of Black women, we identified 628 DNAm sites significantly associated with BMI. Using a more stringent significance threshold of Bonferroni\u2010corrected <jats:italic>p<\/jats:italic> value 0.05, 65 and 61 DNAm sites associated with BMI were identified from the combined sex and female\u2010only meta\u2010analyses, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that BMI is associated with differences in DNAm among women that can be identified with DNA extracted from salivary (discovery) and peripheral blood (replication) samples among Black populations across two cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23589","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T15:46:20Z","timestamp":1670427980000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Epigenome\u2010wide association study of BMI in Black populations from InterGEN and GENOA"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-7358","authenticated-orcid":false,"given":"Jacquelyn Y.","family":"Taylor","sequence":"first","affiliation":[{"name":"Center for Research on People of Color Columbia University School of Nursing  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Emory University Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-8740","authenticated-orcid":false,"given":"Michelle L.","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Nursing The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Emory University Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Emory University Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Potts\u2010Thompson","sequence":"additional","affiliation":[{"name":"Center for Research on People of Color Columbia University School of Nursing  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Barcelona","sequence":"additional","affiliation":[{"name":"Center for Research on People of Color Columbia University School of Nursing  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Prescott","sequence":"additional","affiliation":[{"name":"Center for Research on People of Color Columbia University School of Nursing  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Emory University Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Crusto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L. 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