{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:00:09Z","timestamp":1791662409568,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity is a growing global concern compounded by limited availability of effective treatment options. The SURMOUNT development program aims to evaluate the efficacy and safety of tirzepatide as an adjunct to lifestyle intervention compared with placebo on chronic weight management in adults with BMI\u2009\u2265\u200927 kg\/m<jats:sup>2<\/jats:sup> with or without type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SURMOUNT program includes four global phase 3 trials NCT04184622 (SURMOUNT\u20101), NCT04657003 (SURMOUNT\u20102), NCT04657016 (SURMOUNT\u20103), and NCT04660643 (SURMOUNT\u20104). Participants are randomized to once\u2010weekly subcutaneous tirzepatide versus placebo in a double\u2010blind manner. The primary end point in all trials is the percentage change in body weight from randomization to end of treatment. Results for the primary end point for SURMOUNT\u20101 were published recently and results for the other trials are expected in 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across trials, participants have a mean age of 44.9 to 54.2\u2009years, are mostly female (50.7% to 69.7%), and have a mean BMI of 36.1 to 38.9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extensive assessment of once\u2010weekly tirzepatide in the global SURMOUNT program will detail the clinical effects of this first\u2010in\u2010class glucose\u2010dependent insulinotropic polypeptide and glucagon\u2010like peptide\u20101 receptor agonist in chronic weight management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23612","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T19:25:47Z","timestamp":1670441147000},"page":"96-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Tirzepatide for the treatment of obesity: Rationale and design of the <scp>SURMOUNT<\/scp> clinical development program"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-5445","authenticated-orcid":false,"given":"Carel W.","family":"le Roux","sequence":"first","affiliation":[{"name":"Diabetes Complications Research Centre University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-9401","authenticated-orcid":false,"given":"Louis J.","family":"Aronne","sequence":"additional","affiliation":[{"name":"Comprehensive Weight Control Center, Division of Endocrinology Diabetes &amp; Metabolism, Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-3705","authenticated-orcid":false,"given":"Robert F.","family":"Kushner","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-8973","authenticated-orcid":false,"given":"Ariana M.","family":"Chao","sequence":"additional","affiliation":[{"name":"University of Pennsylvania School of Nursing  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Machineni","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine UNC School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dunn","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farai B.","family":"Chigutsa","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia N.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-6705","authenticated-orcid":false,"given":"Mathijs C.","family":"Bunck","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization.Obesity and overweight. 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