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Biomarker concentrations were determined using nuclear magnetic resonance spectroscopy. Mixed models assessed for a time effect, group effect, or group by time interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All groups significantly improved body weight (time: <jats:italic>p<\/jats:italic> &lt;\u20090.0001), Lipoprotein Insulin Resistance Index score (time: <jats:italic>p<\/jats:italic> &lt;\u20090.0001), Diabetes Risk Index score (time: <jats:italic>p<\/jats:italic> &lt;\u20090.0001), branched\u2010chain amino acid concentration (time: <jats:italic>p<\/jats:italic> &lt;\u20090.0001), and GlycA concentration (time: <jats:italic>p<\/jats:italic> &lt;\u20090.0001), with no group effect or group by time interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate\u2010intensity physical activity to a diet\u2010only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23618","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T15:48:08Z","timestamp":1673279288000},"page":"338-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of behavioral weight\u2010loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-8980","authenticated-orcid":false,"given":"Katherine A.","family":"Collins","sequence":"first","affiliation":[{"name":"Duke Molecular Physiology Institute and Department of Medicine Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Duke Molecular Physiology Institute and Department of Medicine Duke University School of Medicine  Durham North Carolina USA"},{"name":"Division of Cardiology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee J.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Wondr Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Duke Molecular Physiology Institute and Department of Medicine Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"},{"name":"Cooperative Studies Program Epidemiology Center\u2010Durham Durham VA Health Care System  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lang","sequence":"additional","affiliation":[{"name":"Center on Aging and Mobility University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik B.","family":"Schelbert","sequence":"additional","affiliation":[{"name":"School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Minneapolis Heart Institute East  Saint Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Duke Molecular Physiology Institute and Department of Medicine Duke University School of Medicine  Durham North Carolina USA"},{"name":"Division of Rheumatology and Immunology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Jakicic","sequence":"additional","affiliation":[{"name":"Division of Physical Activity and Weight Management, Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"2627","article-title":"Worldwide trends in body mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population\u2010based measurement studies in 128.9 million children, adolescents, and adults","author":"NCD Risk Factor Collaboration (NCD\u2010RisC)","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_12_3_1","unstructured":"World Obesity Federation.Obesity: missing the 2025 global targets: trends costs and country reports. 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