{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:21:18Z","timestamp":1783419678345,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA134274"],"award-info":[{"award-number":["P30CA134274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA104670"],"award-info":[{"award-number":["R01CA104670"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA214783"],"award-info":[{"award-number":["R01CA214783"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6 RX003977"],"award-info":[{"award-number":["IK6 RX003977"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Body mass index (BMI) does not directly measure adiposity, whereas dual\u2010energy x\u2010ray absorptiometry (DXA) provides valid direct estimates of adiposity. Therefore, this study evaluated usefulness of BMI as a measure of adiposity in serum metabolomics studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional analysis was conducted of 202 women aged 25 to 29\u2009years in the Dietary Intervention Study in Children Follow\u2010Up Study. Heights and weights were measured, and body composition was quantified using clinical DXA protocols. Serum metabolomic profiling was performed by liquid chromatography\u2013tandem mass spectrometry. Partial correlations of BMI, percentage fat (%FAT), and total fat (TOTFAT) with log transformed serum metabolites were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was significant overlap in the 93 metabolites that correlated with BMI, %FAT, and\/or TOTFAT; 9 differently correlated with BMI and %FAT, whereas 15\u00a0differently correlated with BMI and TOTFAT. Even for these metabolites, absolute differences were modest. Metabolite set enrichment analysis identified diacylglycerol and sphingolipid metabolism as overrepresented among metabolites significantly correlated with all three measures of adiposity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BMI can be a good proxy for DXA measured %FAT and TOTFAT in descriptive metabolomic studies of healthy, young White women. Larger studies in more diverse populations are needed to endorse more generalized conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23619","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:15:41Z","timestamp":1673828141000},"page":"525-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A comparison of associations of body mass index and dual\u2010energy x\u2010ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-4588","authenticated-orcid":false,"given":"Joanne F.","family":"Dorgan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-110X","authenticated-orcid":false,"given":"Alice S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-3432","authenticated-orcid":false,"given":"Erin S.","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Center for Health Research  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Van Horn","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence S.","family":"Magder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda G.","family":"Snetselaar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Iowa College of Public Health  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cher M.","family":"Dallal","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of Maryland School of Public Health  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungyoun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science &amp; Food Management Ewha Womans University  Seoul South Korea"},{"name":"Graduate Program in System Health Science &amp; Engineering Ewha Womans University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-2541","authenticated-orcid":false,"given":"John A.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Hawaii at Manoa  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Prevalence of obesity and severe obesity among adults: United States, 2017\u20132018","author":"Hales CM","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6134362"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88883"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.12.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq306"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162164"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2014.11.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/862514"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0814"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803026"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab388"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(93)90067-E"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.256"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1259"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-019-01256-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfz026"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jesp.2013.03.013"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121945"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3200\/GENP.135.1.105-112"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0509"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102431\u201013\u201099"},{"key":"e_1_2_10_27_1","first-page":"348","article-title":"Relationship between anthropometric and dual energy x\u2010ray absorptiometry measures to assess total and regional adiposity in Malaysian adolescents","volume":"22","author":"Foo L","year":"2013","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1982-3"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051305"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-6331-9_1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0574-1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2555"},{"key":"e_1_2_10_33_1","first-page":"1352","article-title":"Metabolites associated with lean mass and adiposity in older black men","volume":"72","author":"Murphy R","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148361"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0490"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11050317"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040954"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.153974"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.006"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1998.tb00690.x"},{"key":"e_1_2_10_41_1","volume-title":"Lipid Research Clinics Population Studies Data Book, I: the Prevalence Study","author":"National Institutes of Health","year":"1980"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.89.3.495"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.23619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.23619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T09:14:59Z","timestamp":1692522899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.23619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,15]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/oby.23619"],"URL":"https:\/\/doi.org\/10.1002\/oby.23619","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,15]]},"assertion":[{"value":"2022-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}