{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:03:00Z","timestamp":1790362980586,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002494"],"award-info":[{"award-number":["UL1TR002494"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK118278"],"award-info":[{"award-number":["DK118278"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK124484"],"award-info":[{"award-number":["DK124484"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK115906"],"award-info":[{"award-number":["K23DK115906"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG065569"],"award-info":[{"award-number":["AG065569"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Decreased insulin sensitivity and impairment of \u03b2\u2010cell function predate and predict development of type 2 diabetes mellitus. Time\u2010restricted eating (TRE) might have a benefit for these parameters. The objective of this pilot study was to investigate this possibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary analysis of a randomized controlled trial comparing 12\u2009weeks of TRE (8\u2010hour eating window) to unrestricted eating (non\u2010TRE) was performed. Participants were adults with overweight or obesity and without diabetes. Two\u2010hour oral glucose tolerance testing was performed at baseline and end\u2010intervention. Glucose tolerance test\u2010derived measures of insulin sensitivity, insulin secretion, and \u03b2\u2010cell function were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants (17 women\/3 men with mean\u2009[SD]\u00a0age 45.5\u2009[12.1]\u2009years and BMI 34.1\u2009[7.5]\u00a0kg\/m<jats:sup>2<\/jats:sup>) with a prolonged eating window (15.4\u2009[0.9]\u00a0hours) were randomized to TRE (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) or non\u2010TRE (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). The quantitative insulin sensitivity check index (QUICKI), Stumvoll index, Avignon index, insulinogenic index, insulin area under the curve\/glucose area under the curve, and oral disposition index did not differ between the TRE and non\u2010TRE groups at end\u2010intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adults with overweight or obesity and without diabetes, TRE did not significantly alter insulin sensitivity, insulin secretion, or \u03b2\u2010cell function over a 12\u2010week intervention. Whether TRE is beneficial in adults with prediabetes or type 2 diabetes mellitus warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23620","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T07:07:05Z","timestamp":1671088025000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Time\u2010restricted eating did not alter insulin sensitivity or \u03b2\u2010cell function in adults with obesity: A randomized pilot study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-5350","authenticated-orcid":false,"given":"Anne E.","family":"Bantle","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kheng Joe","family":"Lau","sequence":"additional","affiliation":[{"name":"Endocrinology Western Wisconsin Health  Baldwin Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Institute University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Malaeb","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Park Nicollet Health Services  Saint Louis Park Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasma","family":"Harindhanavudhi","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Metabolism, Department of Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily N. 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