{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:01:00Z","timestamp":1789552860545,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["EFSD\/Lilly Young Investigator Research Award"],"award-info":[{"award-number":["EFSD\/Lilly Young Investigator Research Award"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prior evidence indicates that individuals\u00a0with obesity have an accelerated intestinal glucose absorption. This cross\u2010sectional study evaluated whether those with overweight or obesity display higher duodenal protein levels of the glucose carriers sodium\u2010glucose cotransporter 1 (SGLT\u20101), glucose transporter 2 (GLUT\u20102), and glucose transporter 5 (GLUT\u20105).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SGLT\u20101, GLUT\u20102, and GLUT\u20105 protein levels were assessed on duodenal mucosa biopsies of 52 individuals without diabetes categorized on the basis of their BMI as lean, with overweight, or with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals\u00a0with overweight and obesity exhibited progressively increased duodenal protein levels of SGLT\u20101 and GLUT\u20105 as compared with the lean group. Conversely, no differences in duodenal GLUT\u20102 abundance were found among the three groups. Univariate analysis showed that SGLT\u20101 and GLUT\u20105 protein levels were positively correlated with BMI, waist circumference, 1\u2010hour post\u2010load glucose, fasting and post\u2010load insulin, and insulin secretion and resistance levels. Furthermore, a positive relationship was detected between intestinal GLUT\u20105 levels and serum uric acid concentrations, a product of fructose metabolism known to be involved in the pathogenesis of obesity and its complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Individuals\u00a0with overweight and obesity display enhanced duodenal SGLT\u20101 and GLUT\u20105 abundance, which correlates with increased postprandial glucose concentrations, insulin resistance, and hyperinsulinemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23653","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T03:17:51Z","timestamp":1675739871000},"page":"724-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Obesity and overweight are linked to increased sodium\u2010glucose cotransporter 1 and glucose transporter 5 levels in duodenum"],"prefix":"10.1002","volume":"31","author":[{"given":"Teresa Vanessa","family":"Fiorentino","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Vito","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Suraci","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Marasco","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Letizia","family":"Hribal","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Luzza","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-7688","authenticated-orcid":false,"given":"Giorgio","family":"Sesti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine University of Rome\u2010Sapienza  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.Obesity and overweight. 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