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Data were independently extracted by two reviewers. A meta\u2010analysis was performed using a random\u2010effects model. The Newcastle\u2010Ottawa Scale and funnel graph were used to assess the quality and publication bias, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 42 studies involving 841,325 individuals were included. Compared with individuals born appropriate for gestational age, individuals born LGA had higher odds of overweight and obesity (odds ratios [OR]\u00a0=\u00a01.44, 95% CI: 1.31\u20101.59), type 1 diabetes (OR\u00a0=\u00a01.28, 95% CI: 1.15\u20101.43), hypertension (OR\u00a0=\u00a01.23, 95% CI: 1.01\u20101.51), and metabolic syndrome (OR\u00a0=\u00a01.43, 95%; CI: 1.05\u20101.96). No significant difference was found in hypertriglyceridemia and hypercholesterolemia. Stratified analyses showed that, compared with individuals born appropriate for gestational age, individuals born LGA had higher odds for overweight and obesity from toddler age to puberty age (toddler age: OR\u00a0=\u00a02.12, 95% CI: 1.22\u20103.70; preschool: OR\u00a0=\u00a01.81, 95% CI: 1.55\u20102.12; school age: OR\u00a0=\u00a01.53, 95% CI: 1.09\u20102.14; puberty: OR\u00a0=\u00a01.40, 95% CI: 1.11\u20101.77).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LGA is associated with increased odds of obesity and metabolic syndrome later in life. Future studies should focus on elucidating the potential mechanisms and identifying risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23701","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T03:23:45Z","timestamp":1682479425000},"page":"1255-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Association of large for gestational age with cardiovascular metabolic risks: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"31","author":[{"given":"Yiyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine The Second Hospital, Cheeloo College of Medicine, Shandong University  Jinan China"},{"name":"Research Unit of Gametogenesis and Health of ART\u2010Offspring, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education 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