{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:02Z","timestamp":1786978322041,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Prader\u2010Willi syndrome (PWS) is a multisystem genetic disorder. Unfortunately, none of several mouse models carrying PWS mutations emulates the entirety of the human PWS phenotype, including hyperphagia plus obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To determine whether housing at thermoneutrality (TN, 30 \u00b0C) permits the development of hyperphagia and obesity in the Snord116del PWS mouse model, the effects of housing three different ages of Snord116del and wild\u2010type (WT) littermates at TN versus room temperature (RT, 22\u201324 \u00b0C) for 8\u2009weeks were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Snord116del mice born and maintained at TN exhibited lower body weight curves, lower percentage fat mass, and lower food intake than WT mice at RT. In 4\u2010 to 6\u2010month\u2010old high\u2010fat diet\u2013fed female mice, TN raised the Snord116del body weight curve closer to that of RT\u2010housed WT mice although the TN\u2010housed Snord116del mice did not gain more adiposity or exhibit greater food intake. In 6\u2010 to 8\u2010month\u2010old high\u2010fat diet\u2013fed male mice, body weight, adiposity, and food intake of TN\u2010housed Snord116del mice remained far below levels in RT\u2010housed WT mice. TN elicited hypotonia in Snord116del adults and exacerbated mortality of Snord116del newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In none of three tested TN protocols were greater food intake, body weight, or adiposity induced in Snord116del mice compared with RT\u2010housed WT mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23766","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T23:35:37Z","timestamp":1683761737000},"page":"1644-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of thermoneutrality on food intake, body weight, and body composition in a Prader\u2010Willi syndrome mouse 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