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This study aimed to investigate CB1R availability in peripheral tissue and brain in young men with overweight versus lean men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Healthy males with high (HR,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) or low (LR,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) obesity risk were studied with\u00a0fluoride 18\u2013labeled FMPEP\u2010\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      positron emission tomography to quantify CB1R availability in abdominal adipose tissue, brown adipose tissue, muscle, and brain. Obesity risk was assessed by BMI, physical exercise habits, and familial obesity risk, including parental overweight, obesity, and type 2 diabetes. To assess insulin sensitivity, fluoro\u2010[\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010deoxy\u20102\u2010D\u2010glucose positron emission tomography during hyperinsulinemic\u2010euglycemic clamp was performed. Serum endocannabinoids were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CB1R availability in abdominal adipose tissue was lower in the HR than in the LR group, whereas no difference was found in other tissues. CB1R availability of abdominal adipose tissue and brain correlated positively with insulin sensitivity and negatively with unfavorable lipid profile, BMI, body adiposity, and inflammatory markers. Serum arachidonoyl glycerol concentration was associated with lower CB1R availability of the whole brain, unfavorable lipid profile, and higher serum inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest endocannabinoid dysregulation already in the preobesity state.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23770","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T12:42:31Z","timestamp":1687869751000},"page":"1844-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-0485","authenticated-orcid":false,"given":"Laura","family":"Pekkarinen","sequence":"first","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"},{"name":"Department of Endocrinology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatu","family":"Kantonen","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"},{"name":"Clinical Neurosciences Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa","family":"Oikonen","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Haaparanta\u2010Solin","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"},{"name":"MediCity Research Laboratory University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aarnio","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Dickens","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre University of Turku  Turku Finland"},{"name":"\u00c5bo Akademi University  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"von Eyken","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre University of Turku  Turku Finland"},{"name":"\u00c5bo Akademi University  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Latva\u2010Rasku","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prince","family":"Dadson","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Kirjavainen","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Rajander","sequence":"additional","affiliation":[{"name":"Turku PET Centre \u00c5bo Akademi University  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Kalliokoski","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Turku University Hospital  Turku Finland"},{"name":"Department of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Nummenmaa","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"},{"name":"Department of Psychology University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-338X","authenticated-orcid":false,"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku  Turku Finland"},{"name":"Department of Endocrinology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization. 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