{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:57:00Z","timestamp":1792155420322,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study (1) investigated the effect of weight loss on whole\u2010body and tissue\u2010specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight\u2010loss\u2010induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this secondary analysis of the European SWEET project, 50 adults (age 18\u201365\u2009years) with overweight or obesity (BMI\u2009\u2265\u200925\u2009kg\/m<jats:sup>2<\/jats:sup>) followed a low\u2010energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual\u2010energy x\u2010ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole\u2010body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7\u2010point oral glucose tolerance test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LED reduced body weight (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). This was accompanied by increased Matsuda index and reduced HIRI (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but no change in MISI (<jats:italic>p<\/jats:italic>\u2009=\u20090.260). Weight loss decreased IHL content (mean [SEM], 3.9%\u2009[0.7%] vs. 1.6%\u2009[0.5%], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the hepatic saturated fatty acid fraction (41.0%\u2009[1.5%] vs. 36.6%\u2009[1.9%], <jats:italic>p<\/jats:italic>\u2009=\u20090.039). The reduced IHL content was associated with an improvement in HIRI (<jats:italic>r<\/jats:italic>\u2009=\u20090.402, <jats:italic>p<\/jats:italic>\u2009=\u20090.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight\u2010loss\u2010induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23773","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T16:42:31Z","timestamp":1687884151000},"page":"1745-1754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of weight loss on whole\u2010body and tissue\u2010specific insulin sensitivity and hepatic lipid content and composition: <scp>SWEET<\/scp> substudy"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-727X","authenticated-orcid":false,"given":"Michelle D.","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacco J. A. J.","family":"Bastings","sequence":"additional","affiliation":[{"name":"Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M. H.","family":"Op den Kamp\u2010Bruls","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"},{"name":"Department of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-4586","authenticated-orcid":false,"given":"Joanne A.","family":"Harrold","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Population Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Kj\u00f8lb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, Faculty of Science University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-3189","authenticated-orcid":false,"given":"Jason C. G.","family":"Halford","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Population Health University of Liverpool  Liverpool UK"},{"name":"School of Psychology University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja C. M.","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Raben","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, Faculty of Science University of Copenhagen  Frederiksberg Denmark"},{"name":"Clinical Research Copenhagen University Hospital\u2013Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-584X","authenticated-orcid":false,"given":"Vera B.","family":"Schrauwen\u2010Hinderling","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"},{"name":"Department of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"},{"name":"Institute for Clinical Diabetology, German Diabetes Center Leibniz Institute for Diabetes Research at Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-3019","authenticated-orcid":false,"given":"Gijs H.","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-3464","authenticated-orcid":false,"given":"Ellen E.","family":"Blaak","sequence":"additional","affiliation":[{"name":"Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Centre<sup>+<\/sup>  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"World Health Organization.Noncommunicable Diseases Country Profiles 2018. 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