{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:25:39Z","timestamp":1768465539312,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prandial hyperinsulinemia after Roux\u2010en\u2010Y gastric bypass surgery (GB), and to lesser degree after sleeve gastrectomy (SG), has been attributed to rapid glucose flux from the gut and increased insulinotropic gut hormones. However, \u03b2\u2010cell sensitivity to exogenous incretin is reduced after GB. This study examines the effect of GB versus SG on prandial glycemia and \u03b2\u2010cell response to increasing concentrations of endogenous incretins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Glucose kinetics, insulin secretion rate (ISR), and incretin responses to 50\u2010g oral glucose ingestion were compared between ten nondiabetic participants with GB versus nine matched individuals with SG and seven nonoperated normal glucose tolerant control individuals (CN) with and without administration of 200\u2009mg of\u00a0sitagliptin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting glucose and hormonal levels were similar among three groups. Increasing plasma concentrations of endogenous incretins by two\u2010 to three\u2010fold diminished prandial glycemia and increased \u03b2\u2010cell secretion in all three groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but insulin secretion per insulin sensitivity (i.e., disposition index) was increased only in GB (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for interaction). However, plot of the slope of ISR (from premeal to peak values) versus plasma glucagon\u2010like peptide\u20101 concentration was smaller after GB compared with SG and CN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After GB, increasing incretin activity augments prandial \u03b2\u2010cell response whereas the \u03b2\u2010cell sensitivity to increasing plasma concentrations of endogenous incretin is diminished.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/oby23872-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23872","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:12:18Z","timestamp":1697699538000},"page":"2774-2785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Differential effect of gastric bypass versus sleeve gastrectomy on insulinotropic action of endogenous incretins"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-739X","authenticated-orcid":false,"given":"Marzieh","family":"Salehi","sequence":"first","affiliation":[{"name":"Division of Diabetes, Department of Medicine University of Texas Health at San Antonio  San Antonio Texas USA"},{"name":"South Texas Veteran Health Care System, Audie Murphy Hospital  San Antonio Texas 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-1651","authenticated-orcid":false,"given":"Amalia","family":"Gastaldelli","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Department of Medicine University of Texas Health at San Antonio  San Antonio Texas USA"},{"name":"Cardiometabolic Risk Unit CNR Institute of Clinical Physiology  Pisa 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