{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:12:35Z","timestamp":1776057155596,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC\u20102017\u2010StG\u2010759161"],"award-info":[{"award-number":["ERC\u20102017\u2010StG\u2010759161"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Insulin resistance is characterized by ectopic fat accumulation leading to cardiac diastolic dysfunction and nonalcoholic fatty liver disease. The objective of this study was to determine whether treatment with the peroxisome proliferator\u2010activated receptor\u2010\u03b1 (PPAR\u03b1) agonist ciprofibrate has direct effects on cardiac and hepatic metabolism and can improve insulin sensitivity and cardiac function in insulin\u2010resistant volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten insulin\u2010resistant male volunteers received 100 mg\/d of ciprofibrate and placebo for 5\u2009weeks in a randomized double\u2010blind crossover study. Insulin\u2010stimulated metabolic rate of glucose (MRgluc) was measured using dynamic <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose\u2010positron emission tomography\u00a0(<jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET). Additionally, cardiac function, whole\u2010body insulin sensitivity, intrahepatic lipid content, skeletal muscle gene expression, 24\u2010hour blood pressure, and substrate metabolism were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whole\u2010body insulin sensitivity, energy metabolism, and body composition were unchanged after ciprofibrate treatment. Ciprofibrate treatment decreased insulin\u2010stimulated hepatic MRgluc and increased hepatic lipid content. Myocardial net MRgluc tended to decrease after ciprofibrate treatment, but ciprofibrate treatment had no effect on cardiac function and cardiac energy status. In addition, no changes in PPAR\u2010related gene expression in muscle were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ciprofibrate treatment increased hepatic lipid accumulation and lowered MRgluc, without affecting whole\u2010body insulin sensitivity. Furthermore, parameters of cardiac function or cardiac energy status were not altered upon ciprofibrate treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23874","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:57:40Z","timestamp":1693983460000},"page":"2493-2504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The tissue\u2010specific metabolic effects of the <scp>PPAR\u03b1<\/scp> agonist ciprofibrate in insulin\u2010resistant male individuals: a double\u2010blind, randomized, placebo\u2010controlled crossover study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-5034","authenticated-orcid":false,"given":"Vera H. 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