{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:24Z","timestamp":1772118804475,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020692","name":"Memphis Research Consortium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Alstr\u00f6m syndrome (AS) is a rare multisystem disorder of which early onset childhood obesity is a cardinal feature. Like humans with AS, animal models with\n                      <jats:italic>Alms1<\/jats:italic>\n                      loss\u2010of\u2010function mutations develop obesity, supporting the notion that ALMS1 is required for the regulatory control of energy balance across species. This study aimed to determine which component(s) of energy balance are reliant on ALMS1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Comprehensive energy balance phenotyping was performed on\n                      <jats:italic>Alms1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>tvrm102<\/jats:italic>\n                      <\/jats:sup>\n                      mice at both 8 and 18\u2009weeks of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      It was found that adiposity gains occurred early and rapidly in\n                      <jats:italic>Alms1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>tvrm102<\/jats:italic>\n                      <\/jats:sup>\n                      male mice but much later in females. Rapid increases in body fat in males were due to a marked reduction in energy expenditure (EE) during early life and not due to any genotype\u2010specific increases in energy intake under chow conditions. Energy intake did increase in a genotype\u2010specific manner when mice were provided a high\u2010fat diet, exacerbating the effects of reduced EE on obesity progression. The EE deficit observed in male\n                      <jats:italic>Alms1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>tvrm102<\/jats:italic>\n                      <\/jats:sup>\n                      mice did not persist as mice aged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Either loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23877","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:11:40Z","timestamp":1694754700000},"page":"2786-2798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Energy expenditure deficits drive obesity in a mouse model of Alstr\u00f6m syndrome"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-408X","authenticated-orcid":false,"given":"Erin J.","family":"Stephenson","sequence":"first","affiliation":[{"name":"Department of Anatomy College of Graduate Studies and Chicago College of Osteopathic Medicine, Midwestern University  Downers Grove Illinois USA"},{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Children's Foundation Research Institute, Le Bonheur Children's Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clint E.","family":"Kinney","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Children's Foundation Research Institute, Le Bonheur Children's Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda S.","family":"Stayton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Children's Foundation Research Institute, Le Bonheur Children's Hospital  Memphis Tennessee USA"},{"name":"Department of Surgery, College of Medicine James D. 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