{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:28:29Z","timestamp":1783960109351,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["6026\u201051000\u2010012\u201006S"],"award-info":[{"award-number":["6026\u201051000\u2010012\u201006S"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM109096"],"award-info":[{"award-number":["P20GM109096"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to quantify the effects of a 4\u2010week, supervised, high\u2010intensity interval training (HIIT) on intrahepatic triglyceride content (IHTG, percentage), cardiorespiratory fitness (CRF), and cardiometabolic markers in adolescents with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 40 adolescents (age 13\u201318 y, BMI 36.7\u2009\u00b1\u20095.8\u2009kg\/m<jats:sup>2<\/jats:sup>) at risk for metabolic dysfunction\u2010associated steatotic liver disease (MASLD) based on obesity and elevated Fibroscan measured controlled attenuation parameter (CAP) scores were randomized to HIIT three times a week for 4\u2009weeks (<jats:italic>n<\/jats:italic>\u2009=\u200934) or observation (control; <jats:italic>n<\/jats:italic>\u2009=\u20096). Liver magnetic resonance imaging proton\u2010density fat\u2010fraction (MRI\u2010PDFF), CAP, oral glucose tolerance test, serum alanine aminotransferase, dual\u2010energy x\u2010ray absorptiometry, and CRF tests were performed before and after intervention. Within\u2010 and between\u2010group differences were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13 (38%) and 4 (66%) children had MASLD by MRI\u2010PDFF (IHTG\u2009\u2265\u20095%) in the HIIT and control groups, respectively. The implemented HIIT protocol had no impact on CRF or IHTG (baseline 5.26%, \u0394\u2009=\u2009\u22120.31 percentage points, 95% CI: \u22120.77 to 0.15; <jats:italic>p<\/jats:italic>\u2009=\u20090.179), but it decreased the 2\u2010h glucose concentration (baseline 116\u2009mg\/dL, \u0394\u2009=\u2009\u221211\u2009mg\/dL; 95% CI: \u221217.6 to \u22125.5; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). When limiting the analysis to participants with MASLD (<jats:italic>n<\/jats:italic>\u2009=\u200917), HIIT decreased IHTG (baseline 8.81%, \u0394\u2009=\u2009\u22121.05 percentage points, 95% CI: \u22122.08 to \u22120.01; <jats:italic>p<\/jats:italic>\u2009=\u20090.048). Between\u2010group comparisons were not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The implemented exercise protocol did not reduce IHTG, but it led to modest improvement in markers of cardiometabolic health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23887","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:25:41Z","timestamp":1695273941000},"page":"2740-2749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of short\u2010term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3759-2778","authenticated-orcid":false,"given":"Emir","family":"Tas","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh College of Medicine  Pittsburgh Pennsylvania 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