{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:04:29Z","timestamp":1790798669444,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017228","name":"European Genomic Institute for Diabetes","doi-asserted-by":"publisher","award":["ANR\u201010\u2010LABX\u20100046"],"award-info":[{"award-number":["ANR\u201010\u2010LABX\u20100046"]}],"id":[{"id":"10.13039\/100017228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Steatotic liver disease (SLD) is frequent in individuals with obesity. In this study, type 2 diabetes (T2D), sex, and menopausal status were combined to refine the stratification of obesity regarding the risk of advanced SLD and gain further insight into disease physiopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 1446 participants with obesity from the ABOS cohort (NCT01129297), who underwent extensive phenotyping, including liver histology and transcriptome profiling. Hierarchical clustering was applied to classify participants. The prevalence of metabolic disorders associated with steatohepatitis (NASH) and liver fibrosis (F\u2009\u2265\u20092) was determined within each identified subgroup and aligned to clinical and biological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of NASH and F\u2009\u2265\u20092 was, respectively, 9.5% (<jats:italic>N<\/jats:italic>\u2009=\u2009138\/1446) and 11.7% (<jats:italic>N<\/jats:italic>\u2009=\u2009159\/1365) in the overall population, 20.3% (<jats:italic>N<\/jats:italic>\u2009=\u2009107\/726) and 21.1% (<jats:italic>N<\/jats:italic>\u2009=\u2009106\/502) in T2D patients, and 3.4% (<jats:italic>N<\/jats:italic>\u2009=\u200931\/920) and 6.1% (<jats:italic>N<\/jats:italic>\u2009=\u200953\/863) in non\u2010T2D patients. NASH and F\u2009\u2265\u20092 prevalence was 15.4% (33\/215) and 15.5% (32\/206) among premenopausal women with T2D vs. 29.5% (33\/112) and 30.3% (<jats:italic>N<\/jats:italic>\u2009=\u200936\/119) in postmenopausal women with T2D (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01); and 21.0% (21\/100) \/ 27.0% (24\/89) in men with T2D\u2009\u2265\u2009age 50 years and 17.9% (17\/95) \/ 18.5% (17\/92) in men with T2D &lt; age 50 years (NS). The distinct contribution of menopause was confirmed by the interaction between sex and age with respect to NASH among T2D patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). Finally, several NASH\u2010associated biological traits (lower platelet count; higher serum uric acid; gamma\u2010glutamyl transferase; aspartate aminotransferase) and liver expressed genes <jats:italic>AKR1B10<\/jats:italic> and <jats:italic>CCL20<\/jats:italic> were significantly associated with menopause in women with T2D but not with age in men with T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study unveiled a remarkably high prevalence of advanced SLD after menopause in women with T2D, associated with a dysfunctional biological liver profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23904","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:32:03Z","timestamp":1700677923000},"page":"3066-3076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-2028","authenticated-orcid":false,"given":"Violeta","family":"Raverdy","sequence":"first","affiliation":[{"name":"University Lille  Lille France"},{"name":"European Genomic Institute for Diabetes  Lille France"},{"name":"INSERM, UMR 1190, Translational Research for Diabetes  Lille France"},{"name":"CHU Lille Integrated Center for Obesity  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Chatelain","sequence":"additional","affiliation":[{"name":"University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41\u2010UAR 2014\u2010PLBS  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lasailly","sequence":"additional","affiliation":[{"name":"University Lille, Inserm, CHU Lille U1286 \u2010 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