{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:08:48Z","timestamp":1790723328809,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to compare the general and metabolic impact of single\u2010anastomosis duodeno\u2010ileal bypass with sleeve gastrectomy (SADI\u2010S) with Roux\u2010en\u2010Y gastric bypass (RYGB) in an obese (ob\/ob) mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>10\u2010week\u2010old male ob\/ob mice underwent either SADI\u2010S, RYGB, or laparotomy surgery (Sham group). General and metabolic parameters were assessed during a 5\u2010week period thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SADI\u2010S induced a deeper weight loss ([mean \u00b1\u2009SEM] \u221241.2%\u2009\u00b1\u20093.3%) than RYGB (\u22125.6%\u2009\u00b1\u20093.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared with the Sham group (+6.3%\u2009\u00b1\u20091.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A significant food restriction was observed after SADI\u2010S only (\u221231%, 117.4\u2009\u00b1\u200910.3 g vs. 170.2\u2009\u00b1\u20095.2\u2009g of food at day 35 in Sham group mice, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Random\u2010fed glycemia and glucose tolerance were more improved after SADI\u2010S than RYGB. SADI\u2010S decreased plasma cholesterol concentration by 60% (0.49\u2009\u00b1\u20090.04 g\/L vs. 1.40\u2009\u00b1\u20090.10\u2009g\/L in the Sham group at day 35, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), significantly more than RYGB (1.04\u2009\u00b1\u20090.14 g\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.018). Plasma sitosterol\/cholesterol and campesterol\/cholesterol ratios were decreased after SADI\u2010S, suggesting a reduced intestinal cholesterol absorption. SADI\u2010S increased exogenous plasma cholesterol\u2010D7 clearance and fecal elimination, also indicating an increased plasma cholesterol excretion. Studying a pair\u2010fed group demonstrated that calorie restriction alone did not explain the beneficial impact of SADI\u2010S.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SADI\u2010S is associated with a greater improvement in lipid and glucose homeostasis than RYGB in ob\/ob mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23916","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:24:50Z","timestamp":1698189890000},"page":"91-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single\u2010anastomosis duodeno\u2010ileal bypass with sleeve gastrectomy improves lipid and glucose homeostasis in ob\/ob mice"],"prefix":"10.1002","volume":"32","author":[{"given":"Samuel","family":"Frey","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, L'institut du thorax  Nantes France"},{"name":"Nantes Universit\u00e9, CHU Nantes, Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Ayer","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, L'institut du thorax  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2375-007X","authenticated-orcid":false,"given":"Thibaud","family":"Sotin","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, L'institut du thorax  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Lorant","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, L'institut du thorax  Nantes 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